please help me answer question 2 on the attached worksheet Name:CHEMISTRY 333Kinetics Practice Problems1.Consider the following set of data and answer the following questions:V (umol/min)[S] (M)6 x 1061 x 102 x 1056 x 1051.8 x 10V (+ inhibitor) (umol/min)20.812-52915452067.6248728a. Plot the data on a Lineweaver-Burk plot (be sure to label axes)b. Determine the Kmc. Determine the Vmaxd. The second set of velocities represents the rate of the reaction whenan inhibitor is added. Plot these data on the same graph as aboveand determine the new Km and Vmax and the type of inhibitor(competitive, uncompetitive, non-competitive).e. Can the effects of the inhibitor be over-ridden by adding moresubstrate? Why?2.The kinetics of an enzyme were analyzed in the absence of inhibitors, aswell as in the presence of Inhibitor A and Inhibitor B. Using the given databelow, construct or calculate the following (Make sure to label graphswith appropriate axes and equations, and circle final answers):No InhibitorInhibitor AInhibitor B[S] mMVo (mmol/min) V, (mmol/min)V2 (mmol/min)33.902.401.2966.003.602.40128.405.103.902410.86.606.303612.07.208.55a. Write out the Michaelis-Menten and Lineweaver-Burke equationsb. Plot all of the data on one plot as Michaelis-Menten saturation curvesc. Plot all of the data on one plot in the Lineweaver-Burk formatd. Define Km and Vmaxe. Mathematically determine the Km and Vmax in the absence and in thepresence of inhibitorsf. Determine what type of inhibitors A and B are

2. Given, [S]mM Velocity -No inhibitor(mmol/minute) Velocity- inhibitor A(mmol/minute) Velocity-…

a. Write out the Michaelis-Menten and Lineweaver-Burke equations b. Plot all of the data on one plot as Michaelis-Menten saturation curves c. Plot all of the data on one plot in the Lineweaver-Burk format d. Define Km and Vmax e. Mathematically determine the Km and Vmax in the absence and in the presence of inhibitors f. Determine what type of inhibitors A and B are

a. Write out the Michaelis-Menten and Lineweaver-Burke equations b. Plot all of the data on one plot as Michaelis-Menten saturation curves c. Plot all of the data on one plot in the Lineweaver-Burk format d. Define Km and Vmax e. Mathematically determine the Km and Vmax in the absence and in the presence of inhibitors f. Determine what type of inhibitors A and B are

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter9: Parenteral Medication Labels And Dosage Calculation

Section: Chapter Questions

Problem 7.7P

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Name: CHEMISTRY 333 Kinetics Practice Problems 1. Consider the following set of data and answer the following questions: V (umol/min) [S] (M) 6 x 106 1 x 10 2 x 105 6 x 105 1.8 x 10 V (+ inhibitor) (umol/min) 20.8 12 -5 29 15 45 20 67.6 24 87 28 a. Plot the data on a Lineweaver-Burk plot (be sure to label axes) b. Determine the Km c. Determine the Vmax d. The second set of velocities represents the rate of the reaction when an inhibitor is added. Plot these data on the same graph as above and determine the new Km and Vmax and the type of inhibitor (competitive, uncompetitive, non-competitive). e. Can the effects of the inhibitor be over-ridden by adding more substrate? Why? 2. The kinetics of an enzyme were analyzed in the absence of inhibitors, as well as in the presence of Inhibitor A and Inhibitor B. Using the given data below, construct or calculate the following (Make sure to label graphs with appropriate axes and equations, and circle final answers): No Inhibitor Inhibitor A…
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