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A. Name the two proteins that induce a negative feedback in this pathway and explain why both feedback mechanisms exist?

A. Name the two proteins that induce a negative feedback in this pathway and explain why both feedback mechanisms exist?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A. Name the two proteins that induce a negative feedback in this pathway and explain why both feedback mechanisms exist? 

B. Discuss how a mutation resulting in an aberrant protein could cause changes in the cell cycle leading to uncontrolled cell division. Explain what the effect of the mutation would be on the protein’s function and what the effect will be on downstream proteins leading to enhanced cell cycle progression

JAK-STAT SIGNALING PATHWAY Ubiquitin me diated jorote olysis ECS complex -- Cytokine-cytokine rečeptor intéraction CIS SOCS STAM Bcl-2 MCLI TC-PTP PIAS + Anti-apoptosis Apoptosis Cytokire Bcl-XL PIMI +p STAT -p DNA STAT Receptor JAK c-Myc CycD + Cell-cycle progression -- Cell-cycle inhibition Homore STAT +u Cell cycle p21 STAT dimerization CBPP300 SLIM TC-PTP SHP1 IRF9 -• Lipid me tabolism GF AOX Proteasome GFAP > Differentiation MAPK signaling pathway SHP2 SOS + Raf Prolife ration Differentiation Ras GRB РІЗК-АКТ tp signaling pathway Cell cycle Cell survival PI3K AKT | MTOR 04630 9/8/20 (c) Kanehisa Laboratories
Transcribed Image Text:JAK-STAT SIGNALING PATHWAY Ubiquitin me diated jorote olysis ECS complex -- Cytokine-cytokine rečeptor intéraction CIS SOCS STAM Bcl-2 MCLI TC-PTP PIAS + Anti-apoptosis Apoptosis Cytokire Bcl-XL PIMI +p STAT -p DNA STAT Receptor JAK c-Myc CycD + Cell-cycle progression -- Cell-cycle inhibition Homore STAT +u Cell cycle p21 STAT dimerization CBPP300 SLIM TC-PTP SHP1 IRF9 -• Lipid me tabolism GF AOX Proteasome GFAP > Differentiation MAPK signaling pathway SHP2 SOS + Raf Prolife ration Differentiation Ras GRB РІЗК-АКТ tp signaling pathway Cell cycle Cell survival PI3K AKT | MTOR 04630 9/8/20 (c) Kanehisa Laboratories
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