A. HUMAN PEDIGREE CASE ANALYSIS 1. One couple has three children with the following sexes and ages: one son (40 y.o.) and two daughters (35 y.o. and 33 y.o.), all of them have normal pigmentation. Another couple has a son (35 y.o) and a daughter (20 y.o.) and all of them also have normal pigmentation. Both couples have normal pigmentation. The younger daughter from the first couple married the son of the second couple and they had three children. Their eldest daughter (5 y.o.) has normal pigmentation while their only son (3 y.o.) and one daughter (1 y.o.) have albinism. a. Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation. b. What is the mode of inheritance of this trait? c. Justify your answer in letter (b). d. For their normal daughter, what is the probability that she is a carrier? Show solution. e. If they will have a fourth child, what is the probability that the child will be albino? Show solution.
A. HUMAN PEDIGREE CASE ANALYSIS
1. One couple has three children with the following sexes and ages: one son (40 y.o.) and two daughters (35 y.o. and 33 y.o.), all of them have normal pigmentation. Another couple has a son (35 y.o) and a daughter (20 y.o.) and all of them also have normal pigmentation. Both couples have normal pigmentation. The younger daughter from the first couple married the son of the second couple and they had three children. Their eldest daughter (5 y.o.) has normal pigmentation while their only son (3 y.o.) and one daughter (1 y.o.) have albinism.
a. Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation.
b. What is the mode of inheritance of this trait?
c. Justify your answer in letter (b).
d. For their normal daughter, what is the probability that she is a carrier? Show solution.
e. If they will have a fourth child, what is the probability that the child will be albino? Show solution.
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