A woman without red-green colorblindness and with a normal chin, whose mother was colorblind, marries a cleft-chinned, non-colorblind man whose mother had a normal chin. Recall that red-green colorblindness is sex-linked recessive, but mid-chin fissure (cleft) is autosomal dominant. What are the expected phenotypic ratios of the children? Show your work.
A woman without red-green colorblindness and with a normal chin, whose mother was colorblind, marries a cleft-chinned, non-colorblind man whose mother had a normal chin. Recall that red-green colorblindness is sex-linked recessive, but mid-chin fissure (cleft) is autosomal dominant. What are the expected phenotypic ratios of the children? Show your work.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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![**Problem: Genetics of Colorblindness and Cleft Chin**
A woman without red-green colorblindness and with a normal chin, whose mother was colorblind, marries a cleft-chinned, non-colorblind man whose mother had a normal chin. Recall that red-green colorblindness is sex-linked recessive, but mid-chin fissure (cleft) is autosomal dominant. What are the expected phenotypic ratios of the children? Show your work.
**Background Information:**
- **Red-Green Colorblindness:**
- Inherited in a sex-linked recessive manner located on the X chromosome.
- Males having one allele (XcY) express the trait due to only one X chromosome.
- Females express the trait when homozygous recessive (XcXc).
- **Cleft Chin:**
- An autosomal dominant trait.
- Expressed in individuals with at least one dominant allele (C) for cleft chin (CC or Cc).
**Phenotypic Ratios Calculation:**
1. **Parental Genotypes:**
- **Mother (woman):**
- Non-colorblind (XNXn) [since her mother was colorblind, she must be a carrier]
- Normal chin (cc)
- **Father (man):**
- Non-colorblind (XNY)
- Cleft chin (Cc) [since his mother had a normal chin, he carries one recessive allele]
2. **Punnett Square Analysis:**
**Colorblindness:**
- Maternal alleles: XN, Xn
- Paternal alleles: XN, Y
- Offspring combinations: XNXN, XNXn, XNY, XnY
**Chin Type:**
- Maternal alleles: c, c
- Paternal alleles: C, c
- Offspring combinations: Cc, Cc, cc, cc
3. **Resulting Phenotypic Ratios:**
- **Non-colorblind & Cleft Chin (Female):** XNXN Cc, XNXn Cc
- **Non-colorblind & Normal Chin (Female):** XNXn cc
- **Colorblind & Cleft Chin (Male):** XnY Cc
- **Colorblind & Normal](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F01fc8d1d-e5b2-4964-a413-6d324e9c2a61%2F0a4fb126-dc39-4be7-a0f0-39b3b024cf93%2F0oaed18_processed.png&w=3840&q=75)
Transcribed Image Text:**Problem: Genetics of Colorblindness and Cleft Chin**
A woman without red-green colorblindness and with a normal chin, whose mother was colorblind, marries a cleft-chinned, non-colorblind man whose mother had a normal chin. Recall that red-green colorblindness is sex-linked recessive, but mid-chin fissure (cleft) is autosomal dominant. What are the expected phenotypic ratios of the children? Show your work.
**Background Information:**
- **Red-Green Colorblindness:**
- Inherited in a sex-linked recessive manner located on the X chromosome.
- Males having one allele (XcY) express the trait due to only one X chromosome.
- Females express the trait when homozygous recessive (XcXc).
- **Cleft Chin:**
- An autosomal dominant trait.
- Expressed in individuals with at least one dominant allele (C) for cleft chin (CC or Cc).
**Phenotypic Ratios Calculation:**
1. **Parental Genotypes:**
- **Mother (woman):**
- Non-colorblind (XNXn) [since her mother was colorblind, she must be a carrier]
- Normal chin (cc)
- **Father (man):**
- Non-colorblind (XNY)
- Cleft chin (Cc) [since his mother had a normal chin, he carries one recessive allele]
2. **Punnett Square Analysis:**
**Colorblindness:**
- Maternal alleles: XN, Xn
- Paternal alleles: XN, Y
- Offspring combinations: XNXN, XNXn, XNY, XnY
**Chin Type:**
- Maternal alleles: c, c
- Paternal alleles: C, c
- Offspring combinations: Cc, Cc, cc, cc
3. **Resulting Phenotypic Ratios:**
- **Non-colorblind & Cleft Chin (Female):** XNXN Cc, XNXn Cc
- **Non-colorblind & Normal Chin (Female):** XNXn cc
- **Colorblind & Cleft Chin (Male):** XnY Cc
- **Colorblind & Normal
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