A) What type of membrane protein is this? Integral, peripheral, monotopic, polytopic? How do you know? Justify your label by features of the protein shown in the image. B) Describe the overall tertiary structure of each protein. Be certain to mention hydrophilicity/hydrophobicity of the surfaces of this protein. C) Provide a detailed description of how each protein is held associated to the biological membrane. Protein 2 Protein 3 Protein 1 "H,N. Exterior Cytosol

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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1. Integral and peripheral membrane proteins employ multiple strategies to keep them associated to a biological membrane. View these three proteins below, and for each protein shown, answer the following questions:

A) What type of membrane protein is this? Integral, peripheral, monotopic, polytopic? How do you know? Justify your label by features of the protein shown in the image.

B) Describe the overall tertiary structure of each protein. Be certain to mention hydrophilicity/hydrophobicity of the surfaces of this protein.

C) Provide a detailed description of how each protein is held associated to the biological membrane.

---

**Protein Descriptions:**

- **Protein 1:**
  - Shown in red, spans the entirety of the membrane, indicating it is integral.
  - Displays multiple helical structures passing through the lipid bilayer, suggesting a polytopic structure.
  - Likely has hydrophobic regions within the membrane and hydrophilic regions at the ends interacting with the aqueous environment.

- **Protein 2:**
  - Illustrated in blue, also spans the lipid membrane, classifying it as integral.
  - Features a beta-barrel structure crossing the membrane, characterized by hydrophobic exteriors in contact with the lipid tails and hydrophilic interiors possibly forming a pore or channel.

- **Protein 3:**
  - Appears to be anchored to one side of the membrane, suggesting it may be a monotopic or peripheral protein.
  - Includes elements interacting with both the membrane surface and cytosol/exterior environment, utilizing varied structural domains that might include hydrophobic moieties for membrane interaction.

**Diagram Explanation:**

- **Protein 1 and Protein 2** display typical characteristics of integral proteins, with multiple transmembrane regions interacting directly with the lipid bilayer.
- **Protein 3** depicts a single-domain or peripheral interaction, relying on specific anchoring to the membrane without spanning the entire bilayer.

These features highlight each protein's unique mechanism of membrane association and structural adaptation for function within biological membranes.
Transcribed Image Text:1. Integral and peripheral membrane proteins employ multiple strategies to keep them associated to a biological membrane. View these three proteins below, and for each protein shown, answer the following questions: A) What type of membrane protein is this? Integral, peripheral, monotopic, polytopic? How do you know? Justify your label by features of the protein shown in the image. B) Describe the overall tertiary structure of each protein. Be certain to mention hydrophilicity/hydrophobicity of the surfaces of this protein. C) Provide a detailed description of how each protein is held associated to the biological membrane. --- **Protein Descriptions:** - **Protein 1:** - Shown in red, spans the entirety of the membrane, indicating it is integral. - Displays multiple helical structures passing through the lipid bilayer, suggesting a polytopic structure. - Likely has hydrophobic regions within the membrane and hydrophilic regions at the ends interacting with the aqueous environment. - **Protein 2:** - Illustrated in blue, also spans the lipid membrane, classifying it as integral. - Features a beta-barrel structure crossing the membrane, characterized by hydrophobic exteriors in contact with the lipid tails and hydrophilic interiors possibly forming a pore or channel. - **Protein 3:** - Appears to be anchored to one side of the membrane, suggesting it may be a monotopic or peripheral protein. - Includes elements interacting with both the membrane surface and cytosol/exterior environment, utilizing varied structural domains that might include hydrophobic moieties for membrane interaction. **Diagram Explanation:** - **Protein 1 and Protein 2** display typical characteristics of integral proteins, with multiple transmembrane regions interacting directly with the lipid bilayer. - **Protein 3** depicts a single-domain or peripheral interaction, relying on specific anchoring to the membrane without spanning the entire bilayer. These features highlight each protein's unique mechanism of membrane association and structural adaptation for function within biological membranes.
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