(a) What do initiation of the urea cycle and initiation of gluconeogenesis have in common? (b) produced, where does it take place, how is it allosterically regulated, and how is the allosteric regulator produced? What is the first committed step of the urea cycle, what reactants are used, what product is

Biochemistry
9th Edition
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Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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4.
The urea cycle was the first metabolic cycle to be discovered, predating the description of
the citric acid cycle by 5 years. Hans Krebs along with Kurt Henseleit used their Warburg manometer
(pictured) to monitor the use of carbon dioxide and ammonia in
the synthesis of urea. In the presence of a slice of liver, urea
could be produced, but the reaction require ornithine and
citrulline. Since citrulline is not consumed during the course of
the enzymatic cycle, but is rather regenerated, Krebs described 2N
citrulline as a "catalyst" of the process.
ОН
ÑH2
(a)
What do initiation of the urea cycle and initiation of gluconeogenesis have in common?
What is the first committed step of the urea cycle, what reactants are used, what product is
(b)
produced, where does it take place, how is it allosterically regulated, and how is the allosteric regulator
produced?
Transcribed Image Text:4. The urea cycle was the first metabolic cycle to be discovered, predating the description of the citric acid cycle by 5 years. Hans Krebs along with Kurt Henseleit used their Warburg manometer (pictured) to monitor the use of carbon dioxide and ammonia in the synthesis of urea. In the presence of a slice of liver, urea could be produced, but the reaction require ornithine and citrulline. Since citrulline is not consumed during the course of the enzymatic cycle, but is rather regenerated, Krebs described 2N citrulline as a "catalyst" of the process. ОН ÑH2 (a) What do initiation of the urea cycle and initiation of gluconeogenesis have in common? What is the first committed step of the urea cycle, what reactants are used, what product is (b) produced, where does it take place, how is it allosterically regulated, and how is the allosteric regulator produced?
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