A study enrolling 30  patients diasnosed with keratitis sicca (KCS) was conducted to determine the effect of a new ocular wetting agent, oker-rinse for improving ocular dryness based on rose-Bengal staining scored. patients were instructed to use oker-rinse in one eye and hypotears, as a control, in other eye 4 times a day for 3 weeks. Rose bengal staining scores were mesured as 0,1,2,3,or 4 in each of four areas of the eye: cornea, limbus, lateral conjunctiva and medical conjunctiva. higher scores represent a greater number of devitalized cells, a condition associated with KCS. the overall scores for each eye were obtained by adding the scores over the four areas. Is there evidence of a difference between the two test preparations in the overall Rose-Bengal staining scores?

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