(a) origin of T cells (b) origin of B cells (c) T cells become immunocompetent (d) B cells become immunocompetent (e) active T cells, B cells, and macrophages wing Yoy 1 Palatine tonsil 2 Submandibular node 3 Cervical node 4 Thymus gland Axillary node 8 Spleen 9 Peyer's patches 10 –5 Intestinal node liac node 11 6 Appendix Inguinal node 12

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Substance Abuse

Substance abuse refers to the use of illegal drugs in excessive quantities, as well as the misuse of legal substances such as prescription or over-the-counter pharmaceuticals or alcohol for purposes other than those intended. Drug addiction, also known as substance use disorder, is a disease that affects the brain and behavior of a person. It leads to a failure to control the use of any drug or prescription, legal or illegal.