A key enzyme of the Citric Acid Cycle is isocitrate dehydrogenase.  It catalyzes the conversion of isocitrate to alpha ketoglutarate.    Given your understanding of the Citric Acid Cycle, how is the activity of isocitrate dehydrogenase likely regulated?   A.  It is activated when fermentation starts.   B.  It is activated when the levels of NADH are low relative to NAD+.   C.  It is activated when levels of ATP are high relative to ADP.   D.  It is inhibited by high levels of pyruvate.

Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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A key enzyme of the Citric Acid Cycle is isocitrate dehydrogenase.  It catalyzes the conversion of isocitrate to alpha ketoglutarate. 

 

Given your understanding of the Citric Acid Cycle, how is the activity of isocitrate dehydrogenase likely regulated?

  •  
    A. 

    It is activated when fermentation starts.

  •  
    B. 

    It is activated when the levels of NADH are low relative to NAD+.

  •  
    C. 

    It is activated when levels of ATP are high relative to ADP.

  •  
    D. 

    It is inhibited by high levels of pyruvate.

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