(a) (i) Draw the structure of ferrocene. (ii) (iii) Ferrocene is a fluxional molecule, briefly explain how you would use 1H NMR to determine this. Illustrate your answer with suitable diagrams. Briefly explain how you would modify the ligand system to prevent ring-whizzing of the Cp ligands. Draw the structure of the modified ferrocene complex. (b) (i) Draw the structures of Ferroquine. (ii) Why is Ferroquine more effective than chloroquine? (iii) Which properties of the Ferroquine molecule are thought to be responsible for its antimalarial properties?

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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(a)
(i)
Draw the structure of ferrocene.
(ii)
(iii)
Ferrocene is a fluxional molecule, briefly explain how you would use 1H NMR to
determine this. Illustrate your answer with suitable diagrams.
Briefly explain how you would modify the ligand system to prevent ring-whizzing of
the Cp ligands. Draw the structure of the modified ferrocene complex.
(b)
(i)
Draw the structures of Ferroquine.
(ii)
Why is Ferroquine more effective than chloroquine?
(iii) Which properties of the Ferroquine molecule are thought to be responsible for its
antimalarial properties?
Transcribed Image Text:(a) (i) Draw the structure of ferrocene. (ii) (iii) Ferrocene is a fluxional molecule, briefly explain how you would use 1H NMR to determine this. Illustrate your answer with suitable diagrams. Briefly explain how you would modify the ligand system to prevent ring-whizzing of the Cp ligands. Draw the structure of the modified ferrocene complex. (b) (i) Draw the structures of Ferroquine. (ii) Why is Ferroquine more effective than chloroquine? (iii) Which properties of the Ferroquine molecule are thought to be responsible for its antimalarial properties?
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