A high-dose treatment of osteosarcoma includes the use of methotrexate at a starting dose of 12 g/m2 as a 4-hour intravenous infusion. For a patient having a BSA of 1.7 m2 and weighing 162 lb, calculate the dose on the basis of mg/kg/min.
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A high-dose treatment of osteosarcoma includes the use of methotrexate at a starting dose of 12
g/m2 as a 4-hour intravenous infusion. For a patient having a BSA of 1.7 m2 and weighing 162 lb,
calculate the dose on the basis of mg/kg/min.
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- The recommended pediatric dose of leuprolide acetate suspension for intramuscular injection is 7.5 mg, once per month, for a child weighing 25 kg. What is the equivalent dose, based on mg/m2, for this child measuring 36 inches in height? Use the BSA equation as needed.A 30-year-old female patient with uncontrolled hypertension is suspected by an investi- gating endocrinologist of having Conn's syndrome. Results of routine biochemistry were (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 2.1 mmol/L 7.2 mmol/L 146 μmol/L 290 IU/L 20 IU/L 49 g/L 8 μmol/L 2.19 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (5-42) (35-50) (<17) (2.12-2.62) (a) Are any of the electrolyte concentrations abnormal, and if so what condition is suggested? (b) What further biochemistry investigations would you undertake? Explain your reasoning.The recommended single dose for acetaminophen is 10.0 to 15.0 mg/kg of body weight for adults. Using this guideline, calculate the maximum single dosage for a person who weighs 133 lb. mg maximum dosage:
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