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A certain protein can bind either of two ligands, A or B. On the graph provided are sketched lines to show the fractional saturation (Y, D) vs. [ligand] for ligand A and ligand В. 1 0.8 B 0.6 0.4 0.2 0. 10 15 20 25 30 35 40 ILigand) (uM) a) What is Kd for ligand A? (Remember to specify units, if any. b) What is Kd for ligand B? (Remember to specify units, if any. c) Which ligand, A or B, binds to the protein with higher affinity (tighter binding)? Briefly explain your reasoning Y (tractional saturation)

A certain protein can bind either of two ligands, A or B. On the graph provided are sketched lines to show the fractional saturation (Y, D) vs. [ligand] for ligand A and ligand В. 1 0.8 B 0.6 0.4 0.2 0. 10 15 20 25 30 35 40 ILigand) (uM) a) What is Kd for ligand A? (Remember to specify units, if any. b) What is Kd for ligand B? (Remember to specify units, if any. c) Which ligand, A or B, binds to the protein with higher affinity (tighter binding)? Briefly explain your reasoning Y (tractional saturation)

Introduction to Chemical Engineering Thermodynamics
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
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A certain protein can bind either of two ligands, A or B. On the graph provided are sketched lines to show the fractional saturation (Y, D) vs. [ligand] for ligand A and ligand В. 1 0.8 0.6 0.4 0.2 10 15 20 25 30 35 40 ILigandl (uM) a) What is Kd for ligand A? (Remember to specify units, if any. b) What is Kd for ligand B? (Remember to specify units, if any. c) Which ligand, A or B, binds to the protein with higher affinity (tighter binding)? Briefly explain your reasoning Y (tractional saturation)
Transcribed Image Text:A certain protein can bind either of two ligands, A or B. On the graph provided are sketched lines to show the fractional saturation (Y, D) vs. [ligand] for ligand A and ligand В. 1 0.8 0.6 0.4 0.2 10 15 20 25 30 35 40 ILigandl (uM) a) What is Kd for ligand A? (Remember to specify units, if any. b) What is Kd for ligand B? (Remember to specify units, if any. c) Which ligand, A or B, binds to the protein with higher affinity (tighter binding)? Briefly explain your reasoning Y (tractional saturation)
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