A cell is being held in G1 phase due to DNA damage caused by UV radiation. When the DNA is damaged, p53 is phorphorylated and prevents entry into what phase? M phase GO phase S phase none of the above
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
![**Question:**
A cell is being held in G1 phase due to DNA damage caused by UV radiation. When the DNA is damaged, p53 is phosphorylated and prevents entry into what phase?
- ○ M phase
- ○ G0 phase
- ○ S phase
- ○ none of the above
**Explanation:**
This question explores the role of the p53 protein in the cell cycle. p53 is a crucial tumor suppressor protein that helps prevent the proliferation of cells with damaged DNA. Upon DNA damage, p53 is activated by phosphorylation, which helps to arrest the cell cycle in the G1 phase. This prevents the cell from progressing to the S phase, where DNA replication occurs, thereby allowing time for DNA repair mechanisms to fix the damage before replication proceeds. The correct answer to this question is "S phase."](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F2f591c64-216a-4120-ac44-1b23dfa641af%2Fc3ee1d15-585d-425f-a001-e38e485b7b7c%2Fzw2jkk_processed.jpeg&w=3840&q=75)
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A cell is being held in G1 phase due to DNA damage caused by UV radiation.
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