A cell is being held in G1 phase due to DNA damage caused by UV radiation. When the DNA is damaged, p53 is phorphorylated and prevents entry into what phase? M phase GO phase S phase none of the above

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Question:**

A cell is being held in G1 phase due to DNA damage caused by UV radiation. When the DNA is damaged, p53 is phosphorylated and prevents entry into what phase?

- ○ M phase
- ○ G0 phase
- ○ S phase
- ○ none of the above

**Explanation:**

This question explores the role of the p53 protein in the cell cycle. p53 is a crucial tumor suppressor protein that helps prevent the proliferation of cells with damaged DNA. Upon DNA damage, p53 is activated by phosphorylation, which helps to arrest the cell cycle in the G1 phase. This prevents the cell from progressing to the S phase, where DNA replication occurs, thereby allowing time for DNA repair mechanisms to fix the damage before replication proceeds. The correct answer to this question is "S phase."
Transcribed Image Text:**Question:** A cell is being held in G1 phase due to DNA damage caused by UV radiation. When the DNA is damaged, p53 is phosphorylated and prevents entry into what phase? - ○ M phase - ○ G0 phase - ○ S phase - ○ none of the above **Explanation:** This question explores the role of the p53 protein in the cell cycle. p53 is a crucial tumor suppressor protein that helps prevent the proliferation of cells with damaged DNA. Upon DNA damage, p53 is activated by phosphorylation, which helps to arrest the cell cycle in the G1 phase. This prevents the cell from progressing to the S phase, where DNA replication occurs, thereby allowing time for DNA repair mechanisms to fix the damage before replication proceeds. The correct answer to this question is "S phase."
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