A 5-year-old boy is brought to the pediatrician's office for an annual visit. The motherreports he has been a sickly infant and often appears drowsy. She also has concerns overher son's persistent thirst and frequent urination. Blood samples are taken for insulinmeasurements at time zero and 1 hour after a glucose loading test. The results of thistesting are illustrated in the table below:Baseline blood sampleControlSerum insulin levels(mU/L)Patient0.86 +/- 21 hour after glucose loadPatient5Control40 +/- 111. What is this information likely to suggest about the underlying biochemical basisfor the patient symptoms?2. What would you predict the patients' fasted blood glucose levels to be given his currentcondition? (e.g. above normal range; within the normal range; below the normal range)3. Based on this diagnosis, what 2 regulatory enzymes are likely to be active in thisindividuals' current condition. Be sure to include a rationale as to why the activity of

Insulin is a hormone that regulates blood glucose levels. When the glucose levels in blood goes…

Answered: A 5-year-old boy is brought to the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Amelia Frankish is 67 years old. She presented to her GP last week, complaining of a very strong headache, followed by dizziness. The symptoms had resolved by the time she could see the GP, who was concerned enough to request a CT (computerised tomography) of Amelia's head and neck. medical history: Diabetes mellitus Type 2: Management: metformin 1000mg, daily enalapril 10 mg daily rosuvastatin 10mg, daily Atrial fibrillation (AF) Management: apixaban 2.5 mg, BD sotalol 40 mg, BD Cigarette smoking: 20 - 30 cigarettes/day, quit 5 years ago. GP diagnosis - one week ago. Amelia underwent a CT scan of the head and neck, but the results were normal. Amelia was assessed as requiring changes to her hypertension & AF management and the following changes made: enalapril ceased the following medications commenced or changed; irbesartan/ hydrochlorothiazide 300/25, daily amlodipine 5mg, daily apixaban 5mg, BD. Today: Amelia woke early this morning at 0600 hours with a 5/10 headache.…
In addition to symptoms of diabetes, which of the following correctly identifies criteria used to diagnose diabetes (select all that apply) O Random plasma glucose concentration > 200 mg/dL. O Fasting plasma glucose > 100 mg/dL. O 2-Hour glucose > 180 mg/dL during a 2 hour post prandial glucose test O Hemoglobin A1C > 6.5%
Becky has been admitted to the paediatric ward from the emergency department after being brought to hospital by her parents due to becoming drowsy at home. Becky is being treated for diabetic ketoacidosis via intravenous insulin and fluids, blood glucose was 36 mmol/l and blood ketones were 3.2 mmol/l on admission. Currently, becky is withdrawn and has said she wants to go home, she says will be ok and that she doesn’t want the treatment. When speaking to mom and dad, they have stated that becky should not be told about the severity of her condition as she will worry too much. Patient Details Name: becky Smith Date of Birth: 13/08/2009 - Age 14 Address: Next Of Kin: Parents, James and Donna Religion: None Ethnic origin: White British Presenting Complaint or Reason for visit Diabetic ketoacidosis (DKA) secondary to recently diagnosed type 1 diabetes (T1DM) Past Medical History T1DM Autism Current Medication Lantus – 12 units - one per day in the evening Novorapid – for administration…
What are the dietary and lifestyle modulation of insulin sensitivity. Current evidence including contoversies and contraindications to improving insulin sensitivity. Dietray factors can be food, food group, dietary model/pattern etc., Lifestyle includes non-dietary factorsy and food related lifestyle factors, e.g timing, restrictions on when food is eaten environment food is eaten in/who it is eater with etc.,
john is passing lots of urine and thirsty and recovering from a flu and has no energy to play sports.GP checks his blood glucose which is 15.8 and ketones 2.5 Part 1 identify what type of diabetes is consistent with john's sympyoms and clinical features.Explain your rationale and the investigations and clinical assessments that should be performed to confirm the diagnosis and type of diabetes for him including when how and why these are perfomed. Part2 Describe the pathophysiology of diabetes in relation to the clinical presentation of john's diabetes.Explain the metabolic abnormalities observed in johns case study in contrast to normal carbohydrate fat and protein metabolism.
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It is 9 am in the morning and David has not eaten since dinner last night at 8 pm. He has fasted for 13 hours. He takes his first, or initial, blood glucose reading and it is 95 mg/dl. He then drinks an 8oz coke and eats 2 glazed donuts. At 9:45 am, 45 minutes after his initial reading, he pricks his finger again and records a blood glucose level of 125 mg/dl. An hour later, at 10:45 am, he takes his final blood sugar reading and it is 108 mg/dl. 1. What is the independent and dependent variable? 2. Why did the glucose level drop? 3. How did the final glucose compare to the intial?

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