A 45-year-old man is being treated with oral levofloxacin for urinary tract infection. The plasma clearance of the drug is calculated as 15.0 L/h. Oral bioavailability of the drug is 75%. Sensitivity analysis of a sputum culture shows a minimal inhibitory concentration of 1 µg/mL for the causative pathogen. The target plasma concentration is 2 mg/L. If the drug is administered twice per day. Which of the following dosages should be administered at each dosing interval to maintain a steady state? (A)300 mg (B) 480 mg (C) 520 mg (D) 600 mg (E) 710 mg
A 45-year-old man is being treated with oral levofloxacin for urinary tract infection. The plasma clearance of the drug is calculated as 15.0 L/h. Oral bioavailability of the drug is 75%. Sensitivity analysis of a sputum culture shows a minimal inhibitory concentration of 1 µg/mL for the causative pathogen. The target plasma concentration is 2 mg/L. If the drug is administered twice per day. Which of the following dosages should be administered at each dosing interval to maintain a steady state? (A)300 mg (B) 480 mg (C) 520 mg (D) 600 mg (E) 710 mg
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A 45-year-old man is being treated with oral levofloxacin for urinary tract infection. The plasma clearance of the drug is calculated as 15.0 L/h. Oral bioavailability of the drug is 75%. Sensitivity analysis of a sputum culture shows a minimal inhibitory concentration of 1 µg/mL for the causative pathogen. The target plasma concentration is 2 mg/L. If the drug is administered twice per day. Which of the following dosages should be administered at each dosing interval to maintain a steady state?
(A)300 mg
(B) 480 mg
(C) 520 mg
(D) 600 mg
(E) 710 mg
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