a) 1,1 C-C disconnection of ketone X gives synthon Y and Z. In the forward synthesis, an ester (for Y) and a Grignard reagent (for Z) could theoretically be used, but this approach is likely to fail. Explain why the reaction would fail and then suggest an alternative synthetic method that can be utilized for the preparation of X. ✓ Z (a) Suggest one possible disconnection for the following target molecule. EIO,C OHC (b) Briefly distinguish between a protecting group and an activating group. Illustrate your answe with a suitable example.

a) 1,1 C-C disconnection of ketone X gives synthon Y and Z. In the forward synthesis, an ester (for Y) and a Grignard reagent (for Z) could theoretically be used, but this approach is likely to fail. Explain why the reaction would fail and then suggest an alternative synthetic method that can be utilized for the preparation of X. ✓ Z (a) Suggest one possible disconnection for the following target molecule. EIO,C OHC (b) Briefly distinguish between a protecting group and an activating group. Illustrate your answe with a suitable example.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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