9. Propose reagents and conditions for the following multistep synthesis, one of steps will be Witting reaction. Propose a mechanism for the Witting reaction.
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![**Question 9:**
Propose reagents and conditions for the following multistep synthesis; one of the steps will be a Wittig reaction. Propose a mechanism for the Wittig reaction.
**Diagram Explanation:**
- The image shows a reaction scheme where a cyclohexanone (a six-membered carbon ring containing a ketone group) is converted into an alkene (a six-membered carbon ring with a propyl group and a double bond at the end).
For this synthesis, the Wittig reaction will be used to convert the carbonyl group of cyclohexanone into the alkene. A Wittig reagent (ylide) will be required for this transformation.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F732551a7-9ea8-4f63-a190-9981677412cc%2Fc25cc60e-51a7-47d1-92f4-9e4e3650607f%2F2lkr8lh_processed.png&w=3840&q=75)
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