9. Given the pka's indicated, determine the net charge on the molecule shown below when it is in aqueous solution at pH 2.3, 7.6 and 14. pka = 5 O pH 2.3 7.6 14 H NH₂ H net pK₂ = 11 charge H pka: = 10
9. Given the pka's indicated, determine the net charge on the molecule shown below when it is in aqueous solution at pH 2.3, 7.6 and 14. pka = 5 O pH 2.3 7.6 14 H NH₂ H net pK₂ = 11 charge H pka: = 10
Chemistry
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![**Problem: Net Charge Determination at Different pH Levels on a Given Molecule**
**9. Given the pKa's indicated, determine the net charge on the molecule shown below when it is in aqueous solution at pH 2.3, 7.6, and 14.**
The molecule's structure includes the following ionizable groups:
- Carboxylic acid group (pKa = 5)
- Phenolic hydroxyl group (pKa = 10)
- Amino group (pKa = 11)
[Image of the molecule with indicated pKa values]
**Net Charge Calculation Table:**
| pH | 2.3 | 7.6 | 14 |
|----|-----|-----|----|
| Net Charge | ___ | ___ | ___ |
**Graph and Diagram Explanation:**
The molecule features three ionizable groups, each with its own pKa value:
- A carboxylic acid group with a pKa of 5.
- A phenolic hydroxyl group with a pKa of 10.
- An amino group with a pKa of 11.
**Determining Charges at Different pH Values:**
- **pH 2.3:**
At pH 2.3, the environment is acidic.
- The carboxylic acid group (pKa = 5) remains protonated and neutral.
- The phenolic group (pKa = 10) remains protonated and neutral.
- The amino group (pKa = 11) remains protonated and positively charged (+1).
Net Charge at pH 2.3: +1
- **pH 7.6:**
At pH 7.6, the environment is near neutral.
- The carboxylic acid group (pKa = 5) will deprotonate and have a negative charge (-1).
- The phenolic group (pKa = 10) remains protonated and neutral.
- The amino group (pKa = 11) remains protonated and positively charged (+1).
Net Charge at pH 7.6: 0
- **pH 14:**
At pH 14, the environment is highly basic.
- The carboxylic acid group (pKa = 5) remains deprotonated and negatively charged (-1).](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fa44093f9-865e-42e2-9761-7238b47b32ab%2F95e08687-af75-4706-bb2b-632b7bbe240d%2F8yxq9sw_processed.png&w=3840&q=75)
Transcribed Image Text:**Problem: Net Charge Determination at Different pH Levels on a Given Molecule**
**9. Given the pKa's indicated, determine the net charge on the molecule shown below when it is in aqueous solution at pH 2.3, 7.6, and 14.**
The molecule's structure includes the following ionizable groups:
- Carboxylic acid group (pKa = 5)
- Phenolic hydroxyl group (pKa = 10)
- Amino group (pKa = 11)
[Image of the molecule with indicated pKa values]
**Net Charge Calculation Table:**
| pH | 2.3 | 7.6 | 14 |
|----|-----|-----|----|
| Net Charge | ___ | ___ | ___ |
**Graph and Diagram Explanation:**
The molecule features three ionizable groups, each with its own pKa value:
- A carboxylic acid group with a pKa of 5.
- A phenolic hydroxyl group with a pKa of 10.
- An amino group with a pKa of 11.
**Determining Charges at Different pH Values:**
- **pH 2.3:**
At pH 2.3, the environment is acidic.
- The carboxylic acid group (pKa = 5) remains protonated and neutral.
- The phenolic group (pKa = 10) remains protonated and neutral.
- The amino group (pKa = 11) remains protonated and positively charged (+1).
Net Charge at pH 2.3: +1
- **pH 7.6:**
At pH 7.6, the environment is near neutral.
- The carboxylic acid group (pKa = 5) will deprotonate and have a negative charge (-1).
- The phenolic group (pKa = 10) remains protonated and neutral.
- The amino group (pKa = 11) remains protonated and positively charged (+1).
Net Charge at pH 7.6: 0
- **pH 14:**
At pH 14, the environment is highly basic.
- The carboxylic acid group (pKa = 5) remains deprotonated and negatively charged (-1).
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