9. Given the pka's indicated, determine the net charge on the molecule shown below when it is in aqueous solution at pH 2.3, 7.6 and 14. pka = 5 O pH 2.3 7.6 14 H NH₂ H net pK₂ = 11 charge H pka: = 10

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**Problem: Net Charge Determination at Different pH Levels on a Given Molecule**

**9. Given the pKa's indicated, determine the net charge on the molecule shown below when it is in aqueous solution at pH 2.3, 7.6, and 14.**

The molecule's structure includes the following ionizable groups:
- Carboxylic acid group (pKa = 5)
- Phenolic hydroxyl group (pKa = 10)
- Amino group (pKa = 11)

[Image of the molecule with indicated pKa values]

**Net Charge Calculation Table:**

| pH | 2.3 | 7.6 | 14 |
|----|-----|-----|----|
| Net Charge | ___ | ___ | ___ |

**Graph and Diagram Explanation:**

The molecule features three ionizable groups, each with its own pKa value:
- A carboxylic acid group with a pKa of 5.
- A phenolic hydroxyl group with a pKa of 10.
- An amino group with a pKa of 11.

**Determining Charges at Different pH Values:**

- **pH 2.3:**
  At pH 2.3, the environment is acidic. 
  - The carboxylic acid group (pKa = 5) remains protonated and neutral.
  - The phenolic group (pKa = 10) remains protonated and neutral.
  - The amino group (pKa = 11) remains protonated and positively charged (+1).

    Net Charge at pH 2.3: +1

- **pH 7.6:**
  At pH 7.6, the environment is near neutral.
  - The carboxylic acid group (pKa = 5) will deprotonate and have a negative charge (-1).
  - The phenolic group (pKa = 10) remains protonated and neutral.
  - The amino group (pKa = 11) remains protonated and positively charged (+1).
  
    Net Charge at pH 7.6: 0

- **pH 14:**
  At pH 14, the environment is highly basic.
  - The carboxylic acid group (pKa = 5) remains deprotonated and negatively charged (-1).
Transcribed Image Text:**Problem: Net Charge Determination at Different pH Levels on a Given Molecule** **9. Given the pKa's indicated, determine the net charge on the molecule shown below when it is in aqueous solution at pH 2.3, 7.6, and 14.** The molecule's structure includes the following ionizable groups: - Carboxylic acid group (pKa = 5) - Phenolic hydroxyl group (pKa = 10) - Amino group (pKa = 11) [Image of the molecule with indicated pKa values] **Net Charge Calculation Table:** | pH | 2.3 | 7.6 | 14 | |----|-----|-----|----| | Net Charge | ___ | ___ | ___ | **Graph and Diagram Explanation:** The molecule features three ionizable groups, each with its own pKa value: - A carboxylic acid group with a pKa of 5. - A phenolic hydroxyl group with a pKa of 10. - An amino group with a pKa of 11. **Determining Charges at Different pH Values:** - **pH 2.3:** At pH 2.3, the environment is acidic. - The carboxylic acid group (pKa = 5) remains protonated and neutral. - The phenolic group (pKa = 10) remains protonated and neutral. - The amino group (pKa = 11) remains protonated and positively charged (+1). Net Charge at pH 2.3: +1 - **pH 7.6:** At pH 7.6, the environment is near neutral. - The carboxylic acid group (pKa = 5) will deprotonate and have a negative charge (-1). - The phenolic group (pKa = 10) remains protonated and neutral. - The amino group (pKa = 11) remains protonated and positively charged (+1). Net Charge at pH 7.6: 0 - **pH 14:** At pH 14, the environment is highly basic. - The carboxylic acid group (pKa = 5) remains deprotonated and negatively charged (-1).
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