8. Given the following reaction sequence, determine the structures of A-B, including proper stereochemistry. Draw the mechanism of each step of this reaction. Note: the 1. and 2. Designations beside reagents denotes that you use the reagents in different steps. While drawing mechanisms, only use reagents in the current step of the reaction you are on. For example, NaH cannot be used in the same step as the chloride below the arrow. Br NaOH DMSO A 1. NaH 2. CI B 1. LDA 2. Br
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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