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- While dehydrating 2-Methlycyclohexanol to 1-Methlycyclohexanol, and 3-Methlycyclohexanol 1)what is the common problem associate with E1 reaction? Discuss the intermediate. 2) Briefly compare and contrast E1 vs E2 Elimination reactions. INclude details such as speed of the reactions in relation to each other, rate-determining steps (E1), and stereochemical requirements (E2). Mention whether the steps of the reactions are reversible and discuss the conditions that can drive the equilibrium to favor product formation.The reaction of cyclohexene with iodobenzene under Heck conditions forms E, a coupling product with the new phenyl group on the allylic carbon, but none of the “expected” coupling product F with the phenyl group bonded directly to the carbon–carbon double bond. Draw a stepwise mechanism that illustrates how E is formed.ollowing is a conjugated d A) ich of the following is A) OCH 3 CHEM 242 Act 2.2 Aromatics Compounds and EAS Reactions 8. Provide a mechanistic and resonance explanation as to why bromination (Br₂/FeBr3) of acetophenone occurs meta compared to bromination of anisole, which occurs para. For simplicity, go ahead and use "Br+" as the electrophile. Draw the mechanism for the reaction and resonance structures of the Substrate before the reaction occurs.
- Example #1: b Example #2: O Predict the substitution pattern when this compound undergoes a Friedel-Crafts alkylation reaction. b b O b Predict the substitution pattern when this compound undergoes a nitration reaction.A) what is the major product if E2 mechanism is followed in the reaction (A-D) B) what is the complete mechanism with steps to form the major productPropose the reagents in best order for the synthesis of the following compound from benzene. CI A) B) 1) CH3CH2Cl, AlCl3 2) Cl₂, AlCl3 3) CH3COCI, AlCl3 1) CH3CH2Cl, AlCl3 2) CH3COCI, AlCl3 3) Cl₂, AlCl3 D) 1) CH3CH2Cl, AlCl3 2) Fuming H₂SO4 2) Cl₂, AlCl3 3) CH3COCI, AlCl3 4) Dilute H2SO4 E) C) 1) CH3COCI, AlCl3 2) Zn(Hg), HCl, Heat 3) Fuming H2SO4 4) Cl₂, AlCl3 5) Dilute H2SO4 1) CH3COCI, AlCl3 2) Cl₂, AlCl3 3) CH3CH2Cl, AlCl3 4) Zn(Hg), HCl, Heat
- Identify the compounds below that cannot be made via a direct Friedel-Crafts alkylation but can be made via acylation followed by a Clemmensen reduction (to avoid carbocation rearrangements). Select all that apply. A) on B) D) O A В C D C C C CWhat is the order of decreasing reactivity towards nucleophilic acyl substitution for the carboxylic acid derivatives? (most reactive first) LOCH₂ BOLOLOK BOLNOM) BC-1-OCK, (CHI)CH-1-OCH, H₂C- H₂C- -C-N(CH3)2 H₂C—C -0 C-CH3 A) II, IV, III, I B I, III, IV, II C) II, I, III, IV D I, II, III, IV I II III IVDraw the chemical structure for product (7) and provide a detailed (a) mechanism for the reaction [4] that explains the stereochemistry of product (8). (m-CPBA = meta-chloroperoxybenzoic acid) m-CPBA Он HCI C9H160 [4] (7) (8) [5] NaOH/H20 C9H1802