7. A student gets the following results after running a TLC plate of several over the counter analgesics. What should the student do to get better results? O Run the TLC for a longer time. O Co-spot the sample several times. O Run a new TLC plate in a less polar solvent. O Run a new TLC in a more polar solvent mixture.
7. A student gets the following results after running a TLC plate of several over the counter analgesics. What should the student do to get better results? O Run the TLC for a longer time. O Co-spot the sample several times. O Run a new TLC plate in a less polar solvent. O Run a new TLC in a more polar solvent mixture.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:**TLC Experiment Improvement Suggestions**
**Problem Statement:**
A student gets the following results after running a TLC plate of several over-the-counter analgesics. What should the student do to get better results?
**Diagram Explanation:**
The diagram depicts a TLC (Thin Layer Chromatography) plate with a baseline featuring five dots. All dots remain at the baseline, suggesting minimal or no movement of the sample spots up the plate.
**Options for Improvement:**
- **Run the TLC for a longer time.**
- Extending the duration might allow compounds more time to separate and move further up the plate.
- **Co-spot the sample several times.**
- Applying multiple layers of the sample might increase the concentration, though if movement isn't occurring, this will not improve results.
- **Run a new TLC plate in a less polar solvent.**
- A less polar solvent might lead to different separation behaviors, but if the compounds are too polar themselves, they may not move much.
- **Run a new TLC in a more polar solvent mixture.**
- Using a more polar solvent could help the compounds move further if they have strong interactions with polar solvents. This is often an effective first strategy.
**Recommendation:**
The most plausible option to achieve better separation, based on the chart, would be to run a new TLC plate in a more polar solvent mixture. This might facilitate the movement of compounds from the baseline.
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