7. A 35-year-old villager with IDDM was examined in the hospital and assured the endocrinologist that he has kept strictly to the recommended diet during insulin treatment. The screening showed that the blood glucose concentration was 6.2 mmol/L; HbA, level was 11.7% (norm 4-6%); no glucose or ketone bodies were detected in the urine. After reviewing the results of laboratory studies, the attending physician was in doubt that the patient followed his nutritional guidelines. Explain this doctor's query. For answer: a) name the reason for the blood HbA, increase; b) list the late complications of diabetes mellitus and explain the molecular mechanisms of their occurrence.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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7. A 35-year-old villager with IDDM was examined in the hospital and assured the
endocrinologist that he has kept strictly to the recommended diet during insulin
treatment. The screening showed that the blood glucose concentration was
6.2 mmol/L; HbA, level was 11.7% (norm 4-6%); no glucose or ketone bodies
were detected in the urine. After reviewing the results of laboratory studies,
the attending physician was in doubt that the patient followed his nutritional
guidelines. Explain this doctor's query. For answer:
a) name the reason for the blood HbA, increase;
b) list the late complications of diabetes mellitus and explain the molecular
mechanisms of their occurrence.
Transcribed Image Text:7. A 35-year-old villager with IDDM was examined in the hospital and assured the endocrinologist that he has kept strictly to the recommended diet during insulin treatment. The screening showed that the blood glucose concentration was 6.2 mmol/L; HbA, level was 11.7% (norm 4-6%); no glucose or ketone bodies were detected in the urine. After reviewing the results of laboratory studies, the attending physician was in doubt that the patient followed his nutritional guidelines. Explain this doctor's query. For answer: a) name the reason for the blood HbA, increase; b) list the late complications of diabetes mellitus and explain the molecular mechanisms of their occurrence.
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