6. You are studying the physiology of hypertension (high blood pressure) using the rat as a model system and wish to breed a strain of rat which has naturally high blood pressure. Systolic blood pressure is a quantitative trait with a continuous phenotypic distribution. It is measured as millimeters of mercury displaced in a blood pressure meter (mm Hg). You start with a base population of normal domestic rats, which has a mean systolic blood pressure of 120 mm Hg. You select the 10% of the rats which have the highest systolic blood pressure. The average systolic blood pressure value of these selected breeders is 140 mm Hg. You then interbreed the selected rats and measure the systolic blood pressure in their progeny. What would be the average systolic blood pressure in the progeny of the selected breeders if A. heritability = 0.5 ? B. heritability = 1.0 ? C. heritability = 0 ? D. In a second experiment, you go back to that same base population of domestic rats and select the 10% of the animals with the lowest average systolic blood pressure. These selected animals have a mean blood pressure of 100 mm Hg. If heritability = 0.5, what would be the average systolic blood pressure in the progeny of these selected breeders in this second experiment?
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
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