5. The target compound below (a potential ẞ-blocker drug) may be prepared using a sulfonium ylide (and then a 2° amine) according to the retrosynthetic scheme shown below. Please perform the following: (a) Draw the structure of a suitable ylide that would accomplish this task and (b) write a mechanism to depict the formation and subsequent usage of the ylide (for the reaction in which the aldehyde is converted into the epoxide)...so the mechanism does NOT have to include the amine + epoxide part of the synthesis. но NR₂ potential class of B-blocker drugs sulfonium ylide H

5. The target compound below (a potential ẞ-blocker drug) may be prepared using a sulfonium ylide (and then a 2° amine) according to the retrosynthetic scheme shown below. Please perform the following: (a) Draw the structure of a suitable ylide that would accomplish this task and (b) write a mechanism to depict the formation and subsequent usage of the ylide (for the reaction in which the aldehyde is converted into the epoxide)...so the mechanism does NOT have to include the amine + epoxide part of the synthesis. но NR₂ potential class of B-blocker drugs sulfonium ylide H

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Diazepam, better known as Valium, is a central nervous system (CNS) sedative/ hypnotic. As a sedative, it diminishes activity and excitement and thereby has a calming effect. Back in 1976, based on the number of new and refilled prescriptions processed, diazepam was the most prescribed drug in the United States. Following is a retrosynthetic analysis for a synthesis of diazepam. Note that the formation of compound B involves a Friedel-Crafts acylation. In this reaction, it is necessary to protect the 2° amine by prior treatment with acetic anhydride. The acetyl-protecting group is then removed by treatment with aqueous NaOH followed by careful acidification with HCl. Q.Given this retrosynthetic analysis, propose a synthesis for diazepam
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