5. The following image is of ASO analysis performed at 90°C on a family with Ty Sachs (M and F are the parents, C1, C2 and C3 are the children), and 2 unrelated controls. These parents had a normal child and then had a child with Ty Sachs and they want to know if their third child will have it. The top ASO dot represents the Ty Sachs allele and the bottom represents the normal allele. TZ N M F C1 Control 1 Control 2
5. The following image is of ASO analysis performed at 90°C on a family with Ty Sachs (M and F are the parents, C1, C2 and C3 are the children), and 2 unrelated controls. These parents had a normal child and then had a child with Ty Sachs and they want to know if their third child will have it. The top ASO dot represents the Ty Sachs allele and the bottom represents the normal allele. TZ N M F C1 Control 1 Control 2
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:5. The following image is of ASO
analysis performed at 90°C on a
family with Ty Sachs (M and F are the
parents, C1, C2 and C3 are the
children), and 2 unrelated controls.
These parents had a normal child and
then had a child with Ty Sachs and
they want to know if their third child
will have it. The top ASO dot
represents the Ty Sachs allele and
the bottom represents the normal
allele.
b. What is the status of the 3 children?
c. What are the controls?
TZ
N
a. What is the status of the parents? (Have disease, are carriers, are normal?)
d. The following panel is of a similar analysis
done, excpet the technician found that the
machine had been set to the wrong
temperature for analysis. Is the temperature
the machine set to higher or lower? Explain
why.
6. A murder victim is found in an advanced state of
decomposition and cannot be identified. Police
suspect that the victim is one of 5 individuals
reported missing by their parents. DNA typing
(RFLP) is carried out against those 5 sets of
parents.
According to loci 1 only, which couple could be the
parents of the dead individual found?
Who are the parents of the individual found
(combine both data)?
According to loci 2 only, which couple could be the
parents of the dead individual found?
M
ΤΖ
F
N
C1
C1
A B C D E
d d d d d d 59 59 x
Control 1
-
Control 1
Control 2
Control 2
A B C D E
6 9 6 2 d 98989 X
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