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5. Adrenoleukodystrophy (ALD) is a rare, inherited metabolic disorder preventing the fatty covering (myelin sheath) on nerve fibers in the brain to form, and the adrenal gland to degenerate, leading to progressive neurological disability and death. It is inherited as an X-linked recessive trait. Mrs. Odone is a carrier of the ALD mutant allele while Mr. Odone is normal. In this case, their son, Lorenzo, has ALD. a. Illustrate the cross. b. Show genotypes and phenotypes of Mrs. Odone, Mr. Odone and Lorenzo. c. If Lorenzo will have a sister, what is the probability that she will have ALD? What about his brother? d. Tell whether each of the following item is TRUE OR FALSE. d.1 A mother who is a carrier has 25% chance of passing the faulty X chromosome to her daughter. d.2 Fathers will always pass the defective gene to their daughters. d.3 A son inherits the defective gene from either the mother or the father. 6. In the mouse, pigment will not be produced in the hair unless the gene C is present. If the individual is CC or Cc; its coat coloration depends upon its genotype with respect to another gene A on a different chromosome. Aa or AA individuals are gray; aa individuals are black. Two gray mice produce litter with gray, albino and black in a ratio of 9:4:3. a. What is the genotype of the parents? b. Show the cross. c. What gene action is involved?

5. Adrenoleukodystrophy (ALD) is a rare, inherited metabolic disorder preventing the fatty covering (myelin sheath) on nerve fibers in the brain to form, and the adrenal gland to degenerate, leading to progressive neurological disability and death. It is inherited as an X-linked recessive trait. Mrs. Odone is a carrier of the ALD mutant allele while Mr. Odone is normal. In this case, their son, Lorenzo, has ALD. a. Illustrate the cross. b. Show genotypes and phenotypes of Mrs. Odone, Mr. Odone and Lorenzo. c. If Lorenzo will have a sister, what is the probability that she will have ALD? What about his brother? d. Tell whether each of the following item is TRUE OR FALSE. d.1 A mother who is a carrier has 25% chance of passing the faulty X chromosome to her daughter. d.2 Fathers will always pass the defective gene to their daughters. d.3 A son inherits the defective gene from either the mother or the father. 6. In the mouse, pigment will not be produced in the hair unless the gene C is present. If the individual is CC or Cc; its coat coloration depends upon its genotype with respect to another gene A on a different chromosome. Aa or AA individuals are gray; aa individuals are black. Two gray mice produce litter with gray, albino and black in a ratio of 9:4:3. a. What is the genotype of the parents? b. Show the cross. c. What gene action is involved?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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5. Adrenoleukodystrophy (ALD) is a rare, inherited metabolic disorder preventing the fatty covering (myelin sheath) on nerve fibers in the brain to form, and the adrenal gland to degenerate, leading to progressive neurological disability and death. It is inherited as an X-linked recessive trait. Mrs. Odone is a carrier of the ALD mutant allele while Mr. Odone is normal. In this case, their son, Lorenzo, has ALD. a. Illustrate the cross. b. Show genotypes and phenotypes of Mrs. Odone, Mr. Odone and Lorenzo. c. If Lorenzo will have a sister, what is the probability that she will have ALD? What about his brother? d. Tell whether each of the following item is TRUE OR FALSE. d.1 A mother who is a carrier has 25% chance of passing the faulty X chromosome to her daughter. d.2 Fathers will always pass the defective gene to their daughters. d.3 A son inherits the defective gene from either the mother or the father. 6. In the mouse, pigment will not be produced in the hair unless the gene C is present. If the individual is CC or Cc; its coat coloration depends upon its genotype with respect to another gene A on a different chromosome. Aa or AA individuals are gray; aa individuals are black. Two gray mice produce litter with gray, albino and black in a ratio of 9:4:3. a. What is the genotype of the parents? b. Show the cross. c. What gene action is involved?
Transcribed Image Text:5. Adrenoleukodystrophy (ALD) is a rare, inherited metabolic disorder preventing the fatty covering (myelin sheath) on nerve fibers in the brain to form, and the adrenal gland to degenerate, leading to progressive neurological disability and death. It is inherited as an X-linked recessive trait. Mrs. Odone is a carrier of the ALD mutant allele while Mr. Odone is normal. In this case, their son, Lorenzo, has ALD. a. Illustrate the cross. b. Show genotypes and phenotypes of Mrs. Odone, Mr. Odone and Lorenzo. c. If Lorenzo will have a sister, what is the probability that she will have ALD? What about his brother? d. Tell whether each of the following item is TRUE OR FALSE. d.1 A mother who is a carrier has 25% chance of passing the faulty X chromosome to her daughter. d.2 Fathers will always pass the defective gene to their daughters. d.3 A son inherits the defective gene from either the mother or the father. 6. In the mouse, pigment will not be produced in the hair unless the gene C is present. If the individual is CC or Cc; its coat coloration depends upon its genotype with respect to another gene A on a different chromosome. Aa or AA individuals are gray; aa individuals are black. Two gray mice produce litter with gray, albino and black in a ratio of 9:4:3. a. What is the genotype of the parents? b. Show the cross. c. What gene action is involved?
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