5-Bromouracil is a compound that is known to induce point mutations in DNA. 1) Out of A/C/G/T as drawn, which nucleobase pairs best with 5-bromouracil? Briefly explain why? ii) The bromine of 5-bromouracil stabilises the alternative tautomeric form of the lactam at position 4. Describe in words the structure of this alternative lactim tautomer of 5-bromouracil. iii) Identify the nucleobase (A/C/G/T) which can best base pair with this alternative tautomer.
5-Bromouracil is a compound that is known to induce point mutations in DNA. 1) Out of A/C/G/T as drawn, which nucleobase pairs best with 5-bromouracil? Briefly explain why? ii) The bromine of 5-bromouracil stabilises the alternative tautomeric form of the lactam at position 4. Describe in words the structure of this alternative lactim tautomer of 5-bromouracil. iii) Identify the nucleobase (A/C/G/T) which can best base pair with this alternative tautomer.
Essentials of Pharmacology for Health Professions
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ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
Problem 11CRQ
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5-Bromouracil is a compound that is known to induce point mutations in DNA.
1) Out of A/C/G/T as drawn, which nucleobase pairs best with 5-bromouracil? Briefly explain why?
ii) The bromine of 5-bromouracil stabilises the alternative tautomeric form of the lactam at position 4.
Describe in words the structure of this alternative lactim tautomer of 5-bromouracil.
iii) Identify the nucleobase (A/C/G/T) which can best base pair with this alternative tautomer.
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