4. In EACH PAIR of drug forms below: (a) Circle which form is the most soluble in water and... (b) Explain your choice using the strongest attractive force between the drug form(s) and water. NH H S CH3 -N- CH3 HO. Na* Penicillin Salt form of penicillin CH, | CH, Methamphetamine (Free Base) Crystal Methamphetamine (salt) H. CH3 CH, Cr O N 0-CH, C-0-CH, Salt Form of Cocaine Free Base Form of Cocaine ("Crack") 22

Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter10: Fuels, Organic Chemicals, And Polymers
Section: Chapter Questions
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In EACH PAIR of drug forms below:
(a) Circle which form is the most soluble in water and . . .
(b) Explain your choice using the strongest attractive force between the drug form(s) and water.

In each pair of drug forms below:

(a) **Circle which form is the most soluble in water and...**

(b) **Explain your choice using the strongest attractive force between the drug form(s) and water.**

**Penicillin:**

1. Structure of penicillin
2. Salt form of penicillin (includes a sodium ion, Na⁺)

**Methamphetamine:**

1. Methamphetamine (Free Base)
2. Crystal Methamphetamine (salt) - features a chloride ion, Cl⁻

**Cocaine:**

1. Salt Form of Cocaine - includes a chloride ion, Cl⁻
2. Free Base Form of Cocaine ("Crack")

**Explanation:**

In these diagrams, the salt forms are generally more soluble in water than the free base forms. This is because the ionic bonds in the salt form interact strongly with water molecules, enhancing solubility. The presence of ions (Na⁺ and Cl⁻) allows for strong ion-dipole interactions with water, a polar solvent.
Transcribed Image Text:In each pair of drug forms below: (a) **Circle which form is the most soluble in water and...** (b) **Explain your choice using the strongest attractive force between the drug form(s) and water.** **Penicillin:** 1. Structure of penicillin 2. Salt form of penicillin (includes a sodium ion, Na⁺) **Methamphetamine:** 1. Methamphetamine (Free Base) 2. Crystal Methamphetamine (salt) - features a chloride ion, Cl⁻ **Cocaine:** 1. Salt Form of Cocaine - includes a chloride ion, Cl⁻ 2. Free Base Form of Cocaine ("Crack") **Explanation:** In these diagrams, the salt forms are generally more soluble in water than the free base forms. This is because the ionic bonds in the salt form interact strongly with water molecules, enhancing solubility. The presence of ions (Na⁺ and Cl⁻) allows for strong ion-dipole interactions with water, a polar solvent.
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