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- 8. A service user with panic disorder has been prescribed 32mg cipramil PO. Oral drops in stock are labelled 40mg/mL. How many mL do you administer?6. What is a racemic mixture? Discuss the advantages and disadvantages of using single isomers of drugs instead of racemic mixtures.In the design of H2 antagonists, the polar guanidine group of compound A was proposed to interact with the antagonist binding region by two hydrogen bonds. This compelled researchers to derivatize compound B from compound A. HN EN Chain Extension Rigidification ZI compound A What drug design strategy has been used here? Simplification H₂N NH Substituent variation HN NH₂ HN NH N compound B
- 9.Name some drugs which can occur drug drug interactions when used with Atenolol? Please answer at your own words?1. A macrolide containing a 15-membered lactone ring Erythromycin Telithromycin Clarithromycin Azithromycin 2. ALL are true about the activity of Macrolides EXCEPT: It is effective against syphilis infections it resembles that of penicillin it is very effective against G(-) bacteria it is effective against erysipelas infections 3. These are ALL causes of bacterial resistance against macrolides EXCEPT: active efflux bacterial endospores release of esterases modification of binding site 4. These are ALL adverse effects of Erythromycin EXCEPT: CYP450 inhibition Hepatotoxicity Neutropenia Acute cholestatic hepatitis 5. These are drugs that have prolonged half-life when taken with erythromycin EXCEPT: Rifampicin Lipitor Lanoxin Lasix1. Relationship of Drug solubility & dissolution rate on Physico-Chemical Properties 2. Relationship of Particle size & effective surface area on Physico-Chemical Properties
- 8. Write the Procainamide introduction, pharmaceutical information, and mechanism of action. Please respond in simple language of your own.1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…21. A loading dose of acetylcysteine (Mucomyst) 8 grams, which is available as a 20% solution (200 mg acetylcysteine per ml) is prescribed by nasogastric tube for a client with acetaminophen toxicity. How many ml of diluent should be added to the medication to obtain a 1:4 concentration? (Enter the numerical value only. If rounding is required, round to the whole number.)
- 1. Study the given drug label and answer the question that follows. Show your solution How many total milliliters of diluent are used? What is the final concentration for each drug? a. b. C. How many milliliters are administered to give amoxicillin 500 mg/clavulanate 125 mg? J 343598 00451 AUGMENTIN 250 mg/5 mL 250 mg/5 mL NDC 43598-004-51 Directions for mixing: Tap bottle until all powder flows freely. Add approximately 2/3 of total water for reconstitution (total=65) shake vigorously to wet powder. Add remaining water, again shake vigorously. Dosage: See accompanying prescribing information. Keep tightly closed. Shake well before using. Must be refrigerated. Diecard after 10 days. Your answer AUGMENTIN® AMOXICILLIN/CLAVULANATE POTASSIUM FOR ORAL SUSPENSION When reconstituted, each 5 mL contains: AMOXICILLIN, 250 MG, as the trihydrate CLAVULANIC ACID, 62.5 MG, as clavulanate potassium 75 mL (when reconstituted) DR.REDDY'S Rx only Use only if inner seal is intact. Not contents:…1. How many ml of propofol (10 mg/ml) is necessary to induce a patient weighing 30 kg for surgery at a dose of 6 mg/kg? 2.How many mL of Midazolam (5mg/ml) should be given to a patient weighing 3.6 kg at a dose of 0.3mg/kg? 3.7. What are the determinants for drug liposolubility?