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3B. Identify the reagents/compounds needed to complete the following synthesis by the Friedel Crafts reaction. p-nitrobenzoyl chloride ? ? O₂N p-nitrobenzophenone 90%

3B. Identify the reagents/compounds needed to complete the following synthesis by the Friedel Crafts reaction. p-nitrobenzoyl chloride ? ? O₂N p-nitrobenzophenone 90%

Organic Chemistry
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter10: Alcohols
Section: Chapter Questions
Problem 10.50P
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**Synthesis of p-Nitrobenzophenone via Friedel-Crafts Reaction** **Problem 3B:** Identify the reagents/compounds required to complete the following synthesis through the Friedel-Crafts reaction. **Reaction Scheme:** Reactant: p-Nitrobenzoyl Chloride (Structure: Benzene ring with a nitro group (NO₂) at the para position and a benzoyl chloride (C=O Cl) group) ? ? (Reagents to be identified) → Product: p-Nitrobenzophenone (Structure: Benzene ring with a nitro group (NO₂) at the para position and a carbonyl group (C=O) bonded to another benzene ring) Yield: 90% **Description:** In this transformation, p-nitrobenzoyl chloride reacts under Friedel-Crafts acylation conditions to form p-nitrobenzophenone with a high yield (90%). The exact reagents needed to facilitate this reaction effectively are to be identified. Typically, Friedel-Crafts acylation requires an aromatic compound (in this case, the benzoyl chloride ring) and a Lewis acid catalyst. **Required Reagents:** To identify the exact reagents required for this synthesis: 1. A Lewis acid catalyst, commonly Aluminum Chloride (AlCl₃), is often used in Friedel-Crafts reactions. 2. An additional benzene ring to attach the acyl group from p-nitrobenzoyl chloride. By implementing these reagents correctly, the acylation reaction proceeds yielding the desired p-nitrobenzophenone. **Graph/Diagram Explanation:** The given chemical structures demonstrate the starting material (p-nitrobenzoyl chloride) and the final product (p-nitrobenzophenone). The transformation process (Friedel-Crafts acylation) is shown with a placeholder ("?") for reagents, implying identification is required for the synthesis completion. This reaction illustrates the importance of employing proper catalysts and conditions to achieve the synthesis of complex organic molecules via classical organic chemistry methods such as Friedel-Crafts acylation.
Transcribed Image Text:**Synthesis of p-Nitrobenzophenone via Friedel-Crafts Reaction** **Problem 3B:** Identify the reagents/compounds required to complete the following synthesis through the Friedel-Crafts reaction. **Reaction Scheme:** Reactant: p-Nitrobenzoyl Chloride (Structure: Benzene ring with a nitro group (NO₂) at the para position and a benzoyl chloride (C=O Cl) group) ? ? (Reagents to be identified) → Product: p-Nitrobenzophenone (Structure: Benzene ring with a nitro group (NO₂) at the para position and a carbonyl group (C=O) bonded to another benzene ring) Yield: 90% **Description:** In this transformation, p-nitrobenzoyl chloride reacts under Friedel-Crafts acylation conditions to form p-nitrobenzophenone with a high yield (90%). The exact reagents needed to facilitate this reaction effectively are to be identified. Typically, Friedel-Crafts acylation requires an aromatic compound (in this case, the benzoyl chloride ring) and a Lewis acid catalyst. **Required Reagents:** To identify the exact reagents required for this synthesis: 1. A Lewis acid catalyst, commonly Aluminum Chloride (AlCl₃), is often used in Friedel-Crafts reactions. 2. An additional benzene ring to attach the acyl group from p-nitrobenzoyl chloride. By implementing these reagents correctly, the acylation reaction proceeds yielding the desired p-nitrobenzophenone. **Graph/Diagram Explanation:** The given chemical structures demonstrate the starting material (p-nitrobenzoyl chloride) and the final product (p-nitrobenzophenone). The transformation process (Friedel-Crafts acylation) is shown with a placeholder ("?") for reagents, implying identification is required for the synthesis completion. This reaction illustrates the importance of employing proper catalysts and conditions to achieve the synthesis of complex organic molecules via classical organic chemistry methods such as Friedel-Crafts acylation.
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