3.2. Consider the reversible product-formation reaction in an enzyme-catalyzed bioreaction: k (ES) E+P E+S: Develop a rate expression for product-formation using the quasi-steady-state approximation and shov that d[P] _ (v,/K„)[S]-(v,/K,)[P] m. v = dt [S] . [P] 1+ Km Kp k, +k, k, k_y +kg where Km and K, = and V, = k,[E,], V, =k¬[E,]. k_2
3.2. Consider the reversible product-formation reaction in an enzyme-catalyzed bioreaction: k (ES) E+P E+S: Develop a rate expression for product-formation using the quasi-steady-state approximation and shov that d[P] _ (v,/K„)[S]-(v,/K,)[P] m. v = dt [S] . [P] 1+ Km Kp k, +k, k, k_y +kg where Km and K, = and V, = k,[E,], V, =k¬[E,]. k_2
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
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Consider the reversible product-formation reaction in an enzyme–catalyzed bioreaction:
Develop a rate expression for product-formation using the quasi-steady-state approximation and show that
![3.2. Consider the reversible product-formation reaction in an enzyme-catalyzed bioreaction:
E+S:
(ES) E+P
Develop a rate expression for product-formation using the quasi-steady-state approximation and show
that
d[P] _ (v,/K„)[S]-(v,/K,)[P]
% =
dt
[S] ¸ [P]
1+
+
K m K,
k+k2
and V, = k,[E,], V, =k¬[E,].
k_2
where Km
k+k,
2 and Kp
k,](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fd28aeac0-630c-4c21-b7ae-d05a7bf03a80%2Ff3c0d0f6-e6af-4221-857a-fdca897e282d%2Fsdgdaa9_processed.png&w=3840&q=75)
Transcribed Image Text:3.2. Consider the reversible product-formation reaction in an enzyme-catalyzed bioreaction:
E+S:
(ES) E+P
Develop a rate expression for product-formation using the quasi-steady-state approximation and show
that
d[P] _ (v,/K„)[S]-(v,/K,)[P]
% =
dt
[S] ¸ [P]
1+
+
K m K,
k+k2
and V, = k,[E,], V, =k¬[E,].
k_2
where Km
k+k,
2 and Kp
k,
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