3. Propose the forward synthesis for the following transformation. Feel free to include any reagents and carbon-basedstarting materials that you might need (it'll be helpful to start with the retrosynthetic analysis), 10 pts:OHOEt

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Answered: 3. Propose the forward synthesis for…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Propose an efficient synthesis for the given transformation. This transformation can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A B E 1) &: 2) 1)A :2) Mg H2, Lindlar's cat. NaH F G H. J 1) MeMgBr; 2) H30* Na, NH3 (1) МСРВА 1) EtMgBr; 2) HBr (xs), heat (RCO3H) H3O+ K L M N dilute H2SÓ4 SOCI2, pyridine 1) BH3-THF; 2) H2O2, NaOH DMP or PCC EtBr
Propose reagents and conditions for Step 1. Account for the fact that the CF3 group is meta directing.
Give detailed Solution with explanation needed
Give detailed Solution with explanation needed
10. Please provide a synthesis for one of the following three compounds using benzaldehyde (C6H5CHO) as the starting material. You may use any other reagents that you need to complete the transformation: .N. HO HO HO Но Br Hint: you will need two steps for the transformation.
3
Propose a reagent for Step 3.
Propose an efficient synthesis for the given transformation. OH This transformation can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) i the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A Br₂, hv F 1) MeMgBr; 2) H3O+ K dilute H₂SO4 B 1); 2) H3O+ G Na, NH3 (1) L DMP or PCC 1); 2) H3O+ H MCPBA (RCO 3H) M SOCI2, pyridine D Mg, diethyl ether I 1) EtMgBr; 2) H3O+ N EtBr E H₂, Lindlar's cat. J HBr (xs), heat O 1) BH3-THF; 2) H₂O2, NaOH
Propose an efficient synthesis for the following transformation: The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A 1) MeMgBr 2) H3O* Na2Cr207, H2SO4, H2O 1) EtMgBr 2) H3O* F dilute H2SO4 t-BUOK conc. H2SO4, heat G H TsCl, pyridine NaOEt H2, Pd
Propose an efficient synthesis for the following transformation: OH H. The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A NaOH 1) MeMgBr; 2) H3O* Na2Cr2O7, H2SO4, H20 t-BUOK F G H. H2, Lindlar's cat. 1) O3; 2) DMS TSCI, py dilute H2SO4 K 1) LIAIH4; 2) DMP or PCC 1) EtMgBr; 2) H3O* 1) BH3-THF; 2) H2O2, NaOH H3O*
Suggest an efficient synthesis for the following transformation: OH OH H- ? ŌH OH The synthesis above can be performed with some combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). There is more than one correct solution, but provide just one answer. A Mel B C EtBr cat. OsO4, NMO D E F NaNH, H2, Lindlar's cat. H2, Pt G H I 1) R₂BH; 2) H2O2, NaOH 1) RCO3 H; 2) H3O+ Na, NH3 (1)
Propose an efficient synthesis for the following transformation: The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as “EBF"). If there is more than one correct solution, provide just one answer. A В C H20, H2SO4, HgSO4 t-BUOK HBr, ROOR D F HC=CNa Br2, hv HBr G H 1) O3 2) H20 1) R2BH 2) H2O2, H2O H2, Pd

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3. Propose the forward synthesis for the following transformation. Feel free to include any reagents and carbon-based starting materials that you might need (it'll be helpful to start with the retrosynthetic analysis), 10 pts: OH OEt