Propose an efficient synthesis for the following transformation: OH The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. t-BUOK HBr, ROOR Na2Cr207, H2SO4, H20 HBr G H H2, Lindlar's cat. 1) MеMgBr; 2) H,0+ TSCI, py dilute H2SO4 I K 1) LIAIH,; 2) H,0+ DMP or PCC conc. H2SO4, heat 1) EtMgBr; 2) H,0+
Reactive Intermediates
In chemistry, reactive intermediates are termed as short-lived, highly reactive atoms with high energy. They rapidly transform into stable particles during a chemical reaction. In specific cases, by means of matrix isolation and at low-temperature reactive intermediates can be isolated.
Hydride Shift
A hydride shift is a rearrangement of a hydrogen atom in a carbocation that occurs to make the molecule more stable. In organic chemistry, rearrangement of the carbocation is very easily seen. This rearrangement can be because of the movement of a carbocation to attain stability in the compound. Such structural reorganization movement is called a shift within molecules. After the shifting of carbocation over the different carbon then they form structural isomers of the previous existing molecule.
Vinylic Carbocation
A carbocation where the positive charge is on the alkene carbon is known as the vinyl carbocation or vinyl cation. The empirical formula for vinyl cation is C2H3+. In the vinyl carbocation, the positive charge is on the carbon atom with the double bond therefore it is sp hybridized. It is known to be a part of various reactions, for example, electrophilic addition of alkynes and solvolysis as well. It plays the role of a reactive intermediate in these reactions.
Cycloheptatrienyl Cation
It is an aromatic carbocation having a general formula, [C7 H7]+. It is also known as the aromatic tropylium ion. Its name is derived from the molecule tropine, which is a seven membered carbon atom ring. Cycloheptatriene or tropylidene was first synthesized from tropine.
Stability of Vinyl Carbocation
Carbocations are positively charged carbon atoms. It is also known as a carbonium ion.
![Propose an efficient synthesis for the following transformation:
OH
The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters
(without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer.
A
В
C
t-BUOK
HBr, ROOR
Na2Cr207, H2S04, H20
HBr
E
F
G
H
H2, Lindlar's cat.
1) МеMgBr; 2) H,о+
TSCI, py
dilute H2SO4
I
J
K
L
1) LIAIH,; 2) H,0+
1) EtMgBr; 2) H,0+
DMP or PCC
conc. H2SO4, heat](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F776b81b2-5984-443d-93b2-d351507602c0%2F316349c3-12cb-429a-bf46-2df576e17265%2Fxxyx25u_processed.png&w=3840&q=75)
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