**Exercise 3: Identification of Stereocenters in Chemical Compounds****Objective:** Identify the stereocenters in the given chemical structures and assign each stereocenter as R or S. Include the Cahn-Ingold-Prelog priorities for each substituent in the chiral center.**Chemical Structures:**1. **Compound 1:** - This structure features a bicyclic framework with an amide linkage. There is a stereocenter where the bicyclic structure, carbonyl group, and nitrogen are bonded. - **Components:** - **Oxygen (Double-bonded)**: Part of a carbonyl group. - **Benzene-like ring**: Fused aromatic structure. - **Nitrogen (Amide link)**: Forms part of the bicyclic structure. - **Consideration for R/S Assignment:** - Identify and rank the substituents around the stereocenter using atomic number priority. 2. **Compound 2:** - This structure contains a phenyl ring connected to a saturated carbon with fluorine, hydrogen, and a methylamine group. - **Components:** - **Fluorine (F)**: Highest atomic number, thus highest priority. - **Hydrogen (H)**: Lowest priority. - **Methylamine (NH/CH3)**: Attached to the stereocenter. - **Phenyl Ring**: Priority determined by chain connectivity and atomic number. - **Consideration for R/S Assignment:** - Follow Cahn-Ingold-Prelog rules to determine the stereochemistry at the chiral center.**Graphs/Diagrams Explanation:**- In both diagrams, stereochemistry is represented by wedges and dashed lines, indicating bonds out of the plane and into the plane, respectively.- The positioning of substituents determines the configuration of each stereocenter. For educational purposes, each stereocenter needs to be analyzed separately to assign R or S configuration following the Cahn-Ingold-Prelog system, which involves:- Assigning priorities to substituents based on atomic number.- Rotating the molecule so that the lowest priority group points away.- Observing the order of rest priorities to assign R (clockwise) or S (counterclockwise).**Note:** Correct stereochemical assignments are crucial for understanding the distinctive 3D arrangements within these molecules, which

For both compounds stereocentres and configuration has been assigned

Answered: 3. Identify the stereocenters in the…

3. Identify the stereocenters in the compounds below and assign each stereocenter as Ror S. Include the Cahn-Ingold-Prelog priorities for each substituent in the chiral center. H F NH H, HN

Chemistry

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ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Stereochemistry and Isomerism

Stereochemistry deals with the three-dimensional structure and properties of molecules. It explains the arrangement of atoms and their manipulation within a molecule in a 3D structure. Stereochemistry can be dealt with all types of molecules. Based on the stereochemistry of a molecule, the physical and chemical properties of the molecules vary.

Question

**Exercise 3: Identification of Stereocenters in Chemical Compounds**

**Objective:**
Identify the stereocenters in the given chemical structures and assign each stereocenter as R or S. Include the Cahn-Ingold-Prelog priorities for each substituent in the chiral center.

**Chemical Structures:**

1. **Compound 1:**

- This structure features a bicyclic framework with an amide linkage. There is a stereocenter where the bicyclic structure, carbonyl group, and nitrogen are bonded.
- **Components:**
- **Oxygen (Double-bonded)**: Part of a carbonyl group.
- **Benzene-like ring**: Fused aromatic structure.
- **Nitrogen (Amide link)**: Forms part of the bicyclic structure.
- **Consideration for R/S Assignment:**
- Identify and rank the substituents around the stereocenter using atomic number priority.

2. **Compound 2:**

- This structure contains a phenyl ring connected to a saturated carbon with fluorine, hydrogen, and a methylamine group.
- **Components:**
- **Fluorine (F)**: Highest atomic number, thus highest priority.
- **Hydrogen (H)**: Lowest priority.
- **Methylamine (NH/CH3)**: Attached to the stereocenter.
- **Phenyl Ring**: Priority determined by chain connectivity and atomic number.
- **Consideration for R/S Assignment:**
- Follow Cahn-Ingold-Prelog rules to determine the stereochemistry at the chiral center.

**Graphs/Diagrams Explanation:**

- In both diagrams, stereochemistry is represented by wedges and dashed lines, indicating bonds out of the plane and into the plane, respectively.
- The positioning of substituents determines the configuration of each stereocenter.

For educational purposes, each stereocenter needs to be analyzed separately to assign R or S configuration following the Cahn-Ingold-Prelog system, which involves:
- Assigning priorities to substituents based on atomic number.
- Rotating the molecule so that the lowest priority group points away.
- Observing the order of rest priorities to assign R (clockwise) or S (counterclockwise).

**Note:** Correct stereochemical assignments are crucial for understanding the distinctive 3D arrangements within these molecules, which

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