3) Propose suitable reagent(s) to accomplish the following transformations. O OH he Na Bity CH304 (a) (b) H Ph mg Br OH

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## Chemical Reaction Proposal Exercise

### Question 3
**Propose suitable reagent(s) to accomplish the following transformations. (4 points each)**

#### Given Reactions:

**(a) Transformation:**
- **Starting Compound:** A ketone with a butyl side chain.
- **Target Compound:** An ester with a hydroxy group on the gamma carbon.

*Proposed Reagents and Conditions:*
- Use *Sodium borohydride (NaBH4)* in *methanol (CH3OH)* to reduce the ketone.

**(b) Transformation:**
- **Starting Compound:** A benzaldehyde.
- **Target Compound:** A secondary alcohol with a phenyl ring.

*Proposed Reagents and Conditions:*
1. React benzaldehyde with phenylmagnesium bromide (PhMgBr) using the Grignard reaction.
2. Hydrate to form the secondary alcohol.

### Notes:
- The handwritten notes include the reagents for part (b): 
  1. PhBr, Mg; 
  2. NaBH4. 
- The proposed answer for part (a) includes specific reaction conditions for reducing a carbonyl group. 

Each transformation involves strategic use of organic reagents to achieve the desired molecular change.
Transcribed Image Text:## Chemical Reaction Proposal Exercise ### Question 3 **Propose suitable reagent(s) to accomplish the following transformations. (4 points each)** #### Given Reactions: **(a) Transformation:** - **Starting Compound:** A ketone with a butyl side chain. - **Target Compound:** An ester with a hydroxy group on the gamma carbon. *Proposed Reagents and Conditions:* - Use *Sodium borohydride (NaBH4)* in *methanol (CH3OH)* to reduce the ketone. **(b) Transformation:** - **Starting Compound:** A benzaldehyde. - **Target Compound:** A secondary alcohol with a phenyl ring. *Proposed Reagents and Conditions:* 1. React benzaldehyde with phenylmagnesium bromide (PhMgBr) using the Grignard reaction. 2. Hydrate to form the secondary alcohol. ### Notes: - The handwritten notes include the reagents for part (b): 1. PhBr, Mg; 2. NaBH4. - The proposed answer for part (a) includes specific reaction conditions for reducing a carbonyl group. Each transformation involves strategic use of organic reagents to achieve the desired molecular change.
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