20. The pedigree to the right shows the results of SSR genotyping of a family. The grandmother is affected with a fully penetrant, adult onset autosomal disease. The exact genetic lesion is not known, but it has been 22 mapped to be 4 centimorgans from the genotyping SSR. What is the likelihood that Child B will suffer from the disease? 13 12 32 a. 2% b. 4% C. 48% d. 50% 12 32 A B

20. The pedigree to the right shows the results of SSR genotyping of a family. The grandmother is affected with a fully penetrant, adult onset autosomal disease. The exact genetic lesion is not known, but it has been 22 mapped to be 4 centimorgans from the genotyping SSR. What is the likelihood that Child B will suffer from the disease? 13 12 32 a. 2% b. 4% C. 48% d. 50% 12 32 A B

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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why is the answer 15% do we assume autosomal dominant translates to heterozygous for the trait rather than homozygous because it thought it was 30%
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97. This family is (picture above) affected with blindness. Individual (IV.1) is clinically unaffected. What is the chance that he is homozygous for the normal allele? A-½ B-% C- almost 0 D-1/3 E- almost 100% ANS: IV TO O 560-556
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4. In this pedigree of another family with hemophilia A. If the woman Il-2 has a son, what is the chance that he is affected? II B. If the woman Il-2 has a daughter, what is the chance 1 2 3 4 III that she is affected? -1 C. If the woman Il-2 has 2 sons, what is the chance that neither will be affected? D. What are the chances that the child of II-4 and Il-5 will be affected?
Below is a pedigree for a family into which Individual III-4 has married. He and his spouse, Individual III-3, are visiting a genetic counselor because they are expecting a baby (Individual IV-1). They want to know the chance that the baby will get the autosomal recessive genetic disease seen in Individual II-2. Overall, in the population, the disease is known to affect 1 in 625 individuals in the population to which this family belongs [assume this frequency is the result of random mating so represents f(aa)] I. II. E III. IV. 1 1 2 2 3 1 3 1 4 2 4 5
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Please write or type out the genotypes of each individual on the pedigree in a clear way
3. For the following crosses, describe the genotype and phenotype frequencies of the offspring. I recommend using Punnett squares for each. Offspring phenotypes and frequencies А - 50% О -50% Parental Offspring genotypes and frequencies Parental genotypes phenotypes LAj x i Ai – 50% ii – 50% A and O Bị x Ai BIB x Ai AA x IBIB Bị x Bi AB x i
20. Based on the pedigree below, what do you know about individual II-3 and II-4? Examine the pedigree below. 1 11 111 IV DO 1 Figure 12-3 They have the disease They are both homozygous recesive *REQU They are both carriers They are both homozygous dominant