2. Warburg assumed that cancer cells required fermentative glucose metabolism due to mitochondrial dysfunction. This notion has since been largely proven incorrect. Instead, there have been a number of proposed rationales as to how the Warburg effect/aerobic glycolysis supports (cancer) cell proliferation. Identify and explain two such hypotheses and why they may not serve as complete mechanistic explanations. Limit your responses to 4 sentences per hypothesis. -it allows cancer cell to make biosynthetic building blocks (nucleotide, lipid, amino acid) more efficiently. -increased demand for NAD+ drives aerobic glycolysis.
2. Warburg assumed that cancer cells required fermentative glucose metabolism due to mitochondrial dysfunction. This notion has since been largely proven incorrect. Instead, there have been a number of proposed rationales as to how the Warburg effect/aerobic glycolysis supports (cancer) cell proliferation. Identify and explain two such hypotheses and why they may not serve as complete mechanistic explanations. Limit your responses to 4 sentences per hypothesis. -it allows cancer cell to make biosynthetic building blocks (nucleotide, lipid, amino acid) more efficiently. -increased demand for NAD+ drives aerobic glycolysis.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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2. Warburg assumed that cancer cells required fermentative glucose metabolism due to
mitochondrial dysfunction. This notion has since been largely proven incorrect. Instead, there have
been a number of proposed rationales as to how the Warburg effect/aerobic glycolysis supports
(cancer) cell proliferation. Identify and explain two such hypotheses and why they may not serve
as complete mechanistic explanations. Limit your responses to 4 sentences per hypothesis.
-it allows cancer cell to make biosynthetic building blocks (nucleotide, lipid, amino acid) more
efficiently.
-increased demand for NAD+ drives aerobic glycolysis.
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