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2. Type of drug Polarity Vd (L) fu Half-life (h) fe Drug A Acid Nonpolar 120 0.5 9 0.13 Drug B Acid Nonpolar 44 0.1 20 0.02 Drug C Base Polar 20 0.4 3 0.95 If GFR is 120 ml/min and urine flow is 1.5 ml/min, which of the drugs has a. highest CL? b. most extensive non-renal CL? c. secreted? d. reabsorbed? e. not reabsorbed? f. sensitive to a change in urine pH? For the drug(s), what is the effect of acidifying the urine on CLR? g. renal CL most affected by coadministration of probenecid (a drug that is highly secreted in the renal tubule)? h. highest plasma concentration after continuous IV infusion of 20 mg/h?

2. Type of drug Polarity Vd (L) fu Half-life (h) fe Drug A Acid Nonpolar 120 0.5 9 0.13 Drug B Acid Nonpolar 44 0.1 20 0.02 Drug C Base Polar 20 0.4 3 0.95 If GFR is 120 ml/min and urine flow is 1.5 ml/min, which of the drugs has a. highest CL? b. most extensive non-renal CL? c. secreted? d. reabsorbed? e. not reabsorbed? f. sensitive to a change in urine pH? For the drug(s), what is the effect of acidifying the urine on CLR? g. renal CL most affected by coadministration of probenecid (a drug that is highly secreted in the renal tubule)? h. highest plasma concentration after continuous IV infusion of 20 mg/h?

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2. Type of drug Polarity Vd (L) fu Half-life (h) fe Drug A Acid c. secreted? d. reabsorbed? Nonpolar 120 0.5 9 0.13 bV Drug B Acid Nonpolar 44 0.1 20 0.02 If GFR is 120 ml/min and urine flow is 1.5 ml/min, which of the drugs has a. highest CL? b. most extensive non-renal CL? Drug C Base Polar 20 0.4 3 0.95 e. not reabsorbed? f. sensitive to a change in urine pH? For the drug(s), what is the effect of acidifying the urine on CLR? g. renal CL most affected by coadministration of probenecid (a drug that is highly secreted in the renal tubule)? h. highest plasma concentration after continuous IV infusion of 20 mg/h?
Transcribed Image Text:2. Type of drug Polarity Vd (L) fu Half-life (h) fe Drug A Acid c. secreted? d. reabsorbed? Nonpolar 120 0.5 9 0.13 bV Drug B Acid Nonpolar 44 0.1 20 0.02 If GFR is 120 ml/min and urine flow is 1.5 ml/min, which of the drugs has a. highest CL? b. most extensive non-renal CL? Drug C Base Polar 20 0.4 3 0.95 e. not reabsorbed? f. sensitive to a change in urine pH? For the drug(s), what is the effect of acidifying the urine on CLR? g. renal CL most affected by coadministration of probenecid (a drug that is highly secreted in the renal tubule)? h. highest plasma concentration after continuous IV infusion of 20 mg/h?
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