2. Researchers were interested in a human syndrome characterized by short stature, hearing loss, premature aging and photosensitivity. Panel A shows the effect of UV on fibroblast survival. Panel B shows the effect of UV on lymphoblast replication. Panel C shows the effect of UV dose on unscheduled DNA synthesis (UDS), which is DNA synthesis that occurs at times other than S-phase. Ignore panel D. Based on these results, generate a possible hypothesis the molecular cause of this syndrome. Name one protein that could be involved and design experiment to test its involvement. Be sure to include appropriate controls. % Survival relative to unirradiated > U UDS/cell (AU) 100 10 0.1 10000 9000 8000 7000 6000 5000 4000 3000 2000 1000 0 0 0 2 4 6 8 UV dose (J/m²) 4 UV dose (J/m³) 8 10 10 -WT -P3 12 14 -WT P2 -P3 12 B Population doublings in 72 h relative to unirradiated O % RRS relative to unirradiated 0.8 O 0.6 0.4 0.2 140 120 100 80 60 40 20 O -WT (L7) --L5 -L6 2 10 4 6 8 UV dose (J/m²) 10 UV dose (J/m²) 15 10 -WT P2 P3 CS 12 20

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
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2. Researchers were interested in a human syndrome characterized by short stature, hearing loss,
premature aging and photosensitivity. Panel A shows the effect of UV on fibroblast survival.
Panel B shows the effect of UV on lymphoblast replication. Panel C shows the effect of UV
dose on unscheduled DNA synthesis (UDS), which is DNA synthesis that occurs at times other
than S-phase. Ignore panel D. Based on these results, generate a possible hypothesis the
molecular cause of this syndrome. Name one protein that could be involved and design
experiment to test its involvement. Be sure to include appropriate controls.
в
100
WT
0.8
P3
10
0.6
0.4
WT (L7)
0.2
L5
-L6
0.1
4 6 8
UV dose (J/m)
2
4
6
8
10
12
14
2
10
12
UV dose (J/m)
10000
140
WT
9000
120
8000
P2
7000
100
P3
WT
6000
CS
P2
80
5000
60
4000
3000
40
2000
20
1000
2
4
8
10
12
10
UV dose (J/m)
15
20
UV dose (J/m)
UDS/cell (AU)
% Survival relative to unirradiated >
% RRS relative to unirradiated O
Population doublings in 72 h
relative to unirradiated
Transcribed Image Text:2. Researchers were interested in a human syndrome characterized by short stature, hearing loss, premature aging and photosensitivity. Panel A shows the effect of UV on fibroblast survival. Panel B shows the effect of UV on lymphoblast replication. Panel C shows the effect of UV dose on unscheduled DNA synthesis (UDS), which is DNA synthesis that occurs at times other than S-phase. Ignore panel D. Based on these results, generate a possible hypothesis the molecular cause of this syndrome. Name one protein that could be involved and design experiment to test its involvement. Be sure to include appropriate controls. в 100 WT 0.8 P3 10 0.6 0.4 WT (L7) 0.2 L5 -L6 0.1 4 6 8 UV dose (J/m) 2 4 6 8 10 12 14 2 10 12 UV dose (J/m) 10000 140 WT 9000 120 8000 P2 7000 100 P3 WT 6000 CS P2 80 5000 60 4000 3000 40 2000 20 1000 2 4 8 10 12 10 UV dose (J/m) 15 20 UV dose (J/m) UDS/cell (AU) % Survival relative to unirradiated > % RRS relative to unirradiated O Population doublings in 72 h relative to unirradiated
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