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2. Answer ALL parts of this question. (a) Perform the retrosynthesis of the local anaesthetic known as tetracaine to 1-methyl-4-nitrobenzene, Figure Q2(a), including under each disconnection arrow the name of the forward reaction. (b) (c) HN Tetracaine NO 2 1-methyl-4-nitrobenzene Figure Q2(a) Tip: Five steps should be required and one of the reagents in the penultimate step will be 2-(dimethylamino)ethan-1-ol. (5 marks) Describe the properties and mode of action of alkylating agents that enable this class of drugs to be effective anticancer drugs. (5 marks) Cyclophosphamide is an example of an anticancer drug that has alkylating properties (Figure Q2c). NH-P CI Cyclophosphamide Cytochrome P450 H₂N OP-N OH Figure Q2c Cytotoxic form Draw a labelled mechanism of action of the cytotoxic form of cyclophosphamide. (10 marks)

2. Answer ALL parts of this question. (a) Perform the retrosynthesis of the local anaesthetic known as tetracaine to 1-methyl-4-nitrobenzene, Figure Q2(a), including under each disconnection arrow the name of the forward reaction. (b) (c) HN Tetracaine NO 2 1-methyl-4-nitrobenzene Figure Q2(a) Tip: Five steps should be required and one of the reagents in the penultimate step will be 2-(dimethylamino)ethan-1-ol. (5 marks) Describe the properties and mode of action of alkylating agents that enable this class of drugs to be effective anticancer drugs. (5 marks) Cyclophosphamide is an example of an anticancer drug that has alkylating properties (Figure Q2c). NH-P CI Cyclophosphamide Cytochrome P450 H₂N OP-N OH Figure Q2c Cytotoxic form Draw a labelled mechanism of action of the cytotoxic form of cyclophosphamide. (10 marks)

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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2. Answer ALL parts of this question. (a) Perform the retrosynthesis of the local anaesthetic known as tetracaine to 1-methyl-4-nitrobenzene, Figure Q2(a), including under each disconnection arrow the name of the forward reaction. (b) (c) HN Tetracaine NO 2 1-methyl-4-nitrobenzene Figure Q2(a) Tip: Five steps should be required and one of the reagents in the penultimate step will be 2-(dimethylamino)ethan-1-ol. (5 marks) Describe the properties and mode of action of alkylating agents that enable this class of drugs to be effective anticancer drugs. (5 marks) Cyclophosphamide is an example of an anticancer drug that has alkylating properties (Figure Q2c). NH-P CI Cyclophosphamide Cytochrome P450 H₂N OP-N OH Figure Q2c Cytotoxic form Draw a labelled mechanism of action of the cytotoxic form of cyclophosphamide. (10 marks)
Transcribed Image Text:2. Answer ALL parts of this question. (a) Perform the retrosynthesis of the local anaesthetic known as tetracaine to 1-methyl-4-nitrobenzene, Figure Q2(a), including under each disconnection arrow the name of the forward reaction. (b) (c) HN Tetracaine NO 2 1-methyl-4-nitrobenzene Figure Q2(a) Tip: Five steps should be required and one of the reagents in the penultimate step will be 2-(dimethylamino)ethan-1-ol. (5 marks) Describe the properties and mode of action of alkylating agents that enable this class of drugs to be effective anticancer drugs. (5 marks) Cyclophosphamide is an example of an anticancer drug that has alkylating properties (Figure Q2c). NH-P CI Cyclophosphamide Cytochrome P450 H₂N OP-N OH Figure Q2c Cytotoxic form Draw a labelled mechanism of action of the cytotoxic form of cyclophosphamide. (10 marks)
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