19. Which compound will elute last in a silica-filled column: 4-Hydroxynitrobenzene or 2- Hydroxynitrobenzene? Why? HO NO₂ LOH NO₂

3. According to the Evan's pKa table, phenol has a pka of 9.95. p-Nitro and m-nitrophenol have pKas of 7.14 and 8.35 respectively. Using resonance structures, explain the observed trends in the acidity of these molecules. OH .NO2 OH HO

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At 25°C, for benzoate ion Kp = 1.54 x 10-10 while for ethanoate ion K = 5.5 x 10-10. Choose the correct answer: Select one: Ethanoate ion is a stronger base than benzoate ion but ethanoic acid is a weaker acid than benzoic acid. Ethanoate ion is a stronger base than benzoate ion but ethanoic acid is a stronger acid than benzoic acid. Ethanoate ion is a weaker base than benzoate ion and ethanoic acid is a weaker acid than benzoic acid. Ethanoate ion is a weaker base than benzoate ion but ethanoic acid is a stronger acid than benzoic acid.

Fix each molecule in the drawing area below so that it has the structure it would have if it were dissolved in a 0.1 (aq) solution of NaOH 3-hydroxypropanoic acid and 1,3-dihydroxy-2-propanone .

Select the best reagents to achieve the following transformation Ph Ph Br HBr HBr, ROOR Br2, H₂O Br2

Rank the relative order of elution of the following sets of compounds, from the fastest eluting compound to the slowest, and explain your assignment. NH2 OH NH2 NH2 4 1 2.

is For part C of this lab, during the work up, we add 30% KOH solution. What is the purpose of adding 30% KOH during the work up? Part C: a-Diethylamino-2,6-dimethylacetanilide H.C HN CH₂CI CH₂ (C₂H-J-NH ● It creates the lidocaine salt It deprotonates the lidocaine It decreases the pH. thus making the product less soluble mp 68-69 lidocaine CH₂N(C₂Hsz It increases the solubility of lidocaine in aqueous phase CH3 5331

Give clear detailed Solution with explanation needed..please avoid handwritten Solution

A. Rank the compounds (shown below) in order of increasing acidity. ов A B C E B: Choose the reagent(s) that would be most likely to complete this reaction. ||| > | > | ||| | > || D ||| | > ||