15-13. You are working in a laboratory on an independent study project. You have some epithelial cells from ahuman growing in a bottle. These cells normally divide throughout life. Before spring break, you replaced themedium (fluid surrounding the cells) with fresh medium and forgot to include any growth factors. Then you wenthome for spring break.A-1. Now that you have come back after vacation, you will probably find that the cells have (grown normally)(arrested at G1/S) (arrested at S/G2) (arrested at G2/M) (grown much more than usual) ANDA-2. When you add the missing growth factor to the medium, the cells will probably start to synthesize (p53)(growth factor receptor) (MPF) (cyclin) (cdk = cyclin dependent kinase) (none of these).B. Ink proteins bind to and inhibit one of the cdk's in the cell cycle. (Ink = INhibitor of Kinase.) Many cancer cellshave mutations in the INK gene(s). (For clarity, the protein name is given in lower case and the gene name in uppercase.) Some cancer cells have normal INK genes but have mutation(s) in the corresponding CDK gene(s) thateliminate cdk-ink protein binding. (Other aspects of cdk function are normal.) Given this information, what wouldyou expect?B-1. Levels of ink activity in tumor cells with mutations in the INK gene should be (normal) (above normal)(below normal) (can't predict).B-2. Levels of ink activity in tumor cells with mutations in the CDK gene should be (normal) (above normal)(below normal) (can't predict).

"Since you have asked multiple questions, we will answer the first question for you. If you want any…

15-13. You are working in a laboratory on an independent study project. You have some epithelial cells from a human growing in a bottle. These cells normally divide throughout life. Before spring break, you replaced the medium (fluid surrounding the cells) with fresh medium and forgot to include any growth factors. Then you went home for spring break. A-1. Now that you have come back after vacation, you will probably find that the cells have (grown normally) (arrested at G1/S) (arrested at S/G2) (arrested at G2/M) (grown much more than usual) AND A-2. When you add the missing growth factor to the medium, the cells will probably start to synthesize (p53) (growth factor receptor) (MPF) (cyclin) (cdk = cyclin dependent kinase) (none of these).

15-13. You are working in a laboratory on an independent study project. You have some epithelial cells from a human growing in a bottle. These cells normally divide throughout life. Before spring break, you replaced the medium (fluid surrounding the cells) with fresh medium and forgot to include any growth factors. Then you went home for spring break. A-1. Now that you have come back after vacation, you will probably find that the cells have (grown normally) (arrested at G1/S) (arrested at S/G2) (arrested at G2/M) (grown much more than usual) AND A-2. When you add the missing growth factor to the medium, the cells will probably start to synthesize (p53) (growth factor receptor) (MPF) (cyclin) (cdk = cyclin dependent kinase) (none of these).

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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GQ9
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