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Loss of function mutations in the BRCA1 tumor suppressor gene dramatically increase the risk of breast, ovarian and prostate cancers. In the general U.S. population, about 1/400 people inherit a mutant BRCA1 allele, but in people of Ashkenazi Jewish descent, the frequency is much higher: about 1/40. Ashkenazis are a subset of all Jewish people, descended from a small group of individuals isolated for a period of time centuries ago by geographic and cultural factors. Based on this information, which of the following Hardy-Weinberg violations seems most likely to explain the higher frequency of BRCA1 alleles in modern day Ashkenazi Jewish people? O Genetic drift (founder or bottleneck effect) O Negative selection against wild type (functional) alleles of BRCA1 in Ashkenazi Jewish people O Inbreeding within the population of Ashkenazi Jewish people O Positive selection on the BRCA1 mutant allele in Ashkenazi Jewish people

Loss of function mutations in the BRCA1 tumor suppressor gene dramatically increase the risk of breast, ovarian and prostate cancers. In the general U.S. population, about 1/400 people inherit a mutant BRCA1 allele, but in people of Ashkenazi Jewish descent, the frequency is much higher: about 1/40. Ashkenazis are a subset of all Jewish people, descended from a small group of individuals isolated for a period of time centuries ago by geographic and cultural factors. Based on this information, which of the following Hardy-Weinberg violations seems most likely to explain the higher frequency of BRCA1 alleles in modern day Ashkenazi Jewish people? O Genetic drift (founder or bottleneck effect) O Negative selection against wild type (functional) alleles of BRCA1 in Ashkenazi Jewish people O Inbreeding within the population of Ashkenazi Jewish people O Positive selection on the BRCA1 mutant allele in Ashkenazi Jewish people

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Loss of function mutations in the BRCA1 tumor suppressor gene dramatically increase the risk of breast, ovarian and prostate cancers. In the general U.S. population, about 1/400 people inherit a mutant BRCA1 allele, but in people of Ashkenazi Jewish descent, the frequency is much higher: about 1/40. Ashkenazis are a subset of all Jewish people, descended from a small group of individuals isolated for a period of time centuries ago by geographic and cultural factors. Based on this information, which of the following Hardy-Weinberg violations seems most likely to explain the higher frequency of BRCA1 alleles in modern day Ashkenazi Jewish people? Genetic drift (founder or bottleneck effect) Negative selection against wild type (functional) alleles of BRCA1 in Ashkenazi Jewish people O Inbreeding within the population of Ashkenazi Jewish people Positive selection on the BRCA1 mutant allele in Ashkenazi Jewish people
Transcribed Image Text:Loss of function mutations in the BRCA1 tumor suppressor gene dramatically increase the risk of breast, ovarian and prostate cancers. In the general U.S. population, about 1/400 people inherit a mutant BRCA1 allele, but in people of Ashkenazi Jewish descent, the frequency is much higher: about 1/40. Ashkenazis are a subset of all Jewish people, descended from a small group of individuals isolated for a period of time centuries ago by geographic and cultural factors. Based on this information, which of the following Hardy-Weinberg violations seems most likely to explain the higher frequency of BRCA1 alleles in modern day Ashkenazi Jewish people? Genetic drift (founder or bottleneck effect) Negative selection against wild type (functional) alleles of BRCA1 in Ashkenazi Jewish people O Inbreeding within the population of Ashkenazi Jewish people Positive selection on the BRCA1 mutant allele in Ashkenazi Jewish people
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