14:42 Thu, 9 May \ \ +84% 个 Drug Development (CH6008_ALL_TY13_23) Kingston University London Recents > CH6008 WS4.docx EXAMPLE OF LONG QUESTION (20 marks) 2. Cyclophosphamide is an anticancer drug that is activated in the body under the action of CYP450 enzymes as shown below (Scheme Q2): H₂N NHO 3A 3B HO N NR2 Cyt P450 enzymes H Cyclophosphamide (R=CH-CH₂CI) Cytotoxic Acrolein alkylating agent (i) Scheme Q2 Redraw Scheme Q2, adding the missing intermediates 3A and 3B as well as the curly arrows that show the mechanism of formation of the active form shown on the right. (6 marks) (ii) Use a suitable illustration for the mechanism of action of the active form of cyclophosphamide. Tip: a simple sketch may be used to depict the biological target. O |b (14 marks) = о 2 <

14:42 Thu, 9 May \ \ +84% 个 Drug Development (CH6008_ALL_TY13_23) Kingston University London Recents > CH6008 WS4.docx EXAMPLE OF LONG QUESTION (20 marks) 2. Cyclophosphamide is an anticancer drug that is activated in the body under the action of CYP450 enzymes as shown below (Scheme Q2): H₂N NHO 3A 3B HO N NR2 Cyt P450 enzymes H Cyclophosphamide (R=CH-CH₂CI) Cytotoxic Acrolein alkylating agent (i) Scheme Q2 Redraw Scheme Q2, adding the missing intermediates 3A and 3B as well as the curly arrows that show the mechanism of formation of the active form shown on the right. (6 marks) (ii) Use a suitable illustration for the mechanism of action of the active form of cyclophosphamide. Tip: a simple sketch may be used to depict the biological target. O |b (14 marks) = о 2 <

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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