12.37. The pedigrees indicated here were obtained with three unrelated families whose members express the same completely penetrant disease caused by a dominant mutation that is linked at a distance of 10 cM from an SSR marker locus with three alleles numbered 1, 2, and 3. The SSR alleles present within each live genotype are indicated below the pedigree symbol. The phenotypes of the newly born labeled individuals-A, B, C, and D-are unknown. a. What is the probability of disease expression in each of these newborn babies? b. Why would a human geneticist be unlikely to use this SSR marker for diagnosis of the genetic disease? 13 | 22 13 22 12 | 32 12 32 12 | 32 12 32 12 32 12 32 A B D
12.37. The pedigrees indicated here were obtained with three unrelated families whose members express the same completely penetrant disease caused by a dominant mutation that is linked at a distance of 10 cM from an SSR marker locus with three alleles numbered 1, 2, and 3. The SSR alleles present within each live genotype are indicated below the pedigree symbol. The phenotypes of the newly born labeled individuals-A, B, C, and D-are unknown. a. What is the probability of disease expression in each of these newborn babies? b. Why would a human geneticist be unlikely to use this SSR marker for diagnosis of the genetic disease? 13 | 22 13 22 12 | 32 12 32 12 | 32 12 32 12 32 12 32 A B D
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:12.37. The pedigrees indicated here were obtained with three unrelated families
whose members express the same completely penetrant disease caused by a
dominant mutation that is linked at a distance of 10 çM from an SSR marker
locus with three alleles numbered 1, 2, and 3. The SSR alleles present within
each live genotype are indicated below the pedigree symbol. The phenotypes of
the newly born labeled individuals-A, B, C, and D-are unknown.
a. What is the probability of disease expression in each of these newborn
babies?
b. Why would a human geneticist be unlikely to use this SSR marker for
diagnosis of the genetic disease?
13
22
13
22
12
32
12
32
12
32
|?
12
32
12
32
12
32
A
B
D
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