12. Draw the most likely product for each set of reactants or write NO REACTION. H H NaOH H H H NaOH O H H NaOH F3C F₂C NaOH H

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Draw the most likely product for each set of reactants or write NO REACTION

**Exercise 12: Reaction Product Prediction**

In this exercise, you are tasked with predicting the most likely product for each set of reactants provided or determining if there will be no reaction. The chemical structures involved in this exercise are pairs of aldehydes or ketones with sodium hydroxide (NaOH) as a reagent. 

**Diagrams:**

1. **First Pair:**
   - Left Structure: A ketone with a tert-butyl group attached to the carbonyl carbon.
   - Right Structure: An aldehyde with an ethyl group attached to the carbonyl carbon.

2. **Second Pair:**
   - Left Structure: A cyclic ketone (cyclohexanone).
   - Right Structure: An aldehyde.

3. **Third Pair:**
   - Left Structure: Benzaldehyde.
   - Right Structure: Cyclohexanone.

4. **Fourth Pair:**
   - Identical Structures: Both are ketones with trifluoromethyl groups adjacent to the carbonyl carbon.

For each pair, consider the possibility of reactions such as aldol condensations, particularly given the presence of NaOH, a strong base that may deprotonate the alpha hydrogen to form enolates, which can then attack other carbonyl compounds to form products.

**Task:** Examine each set of reactants and propose the most likely reaction product based on their chemical structures and the presence of NaOH, considering factors such as reactivity and sterics. If a reaction isn't feasible, indicate "NO REACTION."
Transcribed Image Text:**Exercise 12: Reaction Product Prediction** In this exercise, you are tasked with predicting the most likely product for each set of reactants provided or determining if there will be no reaction. The chemical structures involved in this exercise are pairs of aldehydes or ketones with sodium hydroxide (NaOH) as a reagent. **Diagrams:** 1. **First Pair:** - Left Structure: A ketone with a tert-butyl group attached to the carbonyl carbon. - Right Structure: An aldehyde with an ethyl group attached to the carbonyl carbon. 2. **Second Pair:** - Left Structure: A cyclic ketone (cyclohexanone). - Right Structure: An aldehyde. 3. **Third Pair:** - Left Structure: Benzaldehyde. - Right Structure: Cyclohexanone. 4. **Fourth Pair:** - Identical Structures: Both are ketones with trifluoromethyl groups adjacent to the carbonyl carbon. For each pair, consider the possibility of reactions such as aldol condensations, particularly given the presence of NaOH, a strong base that may deprotonate the alpha hydrogen to form enolates, which can then attack other carbonyl compounds to form products. **Task:** Examine each set of reactants and propose the most likely reaction product based on their chemical structures and the presence of NaOH, considering factors such as reactivity and sterics. If a reaction isn't feasible, indicate "NO REACTION."
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