10. (15 pts) (a) Saquinavir is an antiviral agent that acts against HIV-protease. Assess the structure in terms of Lipinski's rules and Veber's parameters (log P = 4.2; polar surface area = 167 Å). (b) Suggest five possible regions in saquinavir that might be susceptible to metabolism and identify the possible metabolite formed. N IZ || H ZI Ill Il Saquinavir I Z H H

10. (15 pts) (a) Saquinavir is an antiviral agent that acts against HIV-protease. Assess the structure in terms of Lipinski's rules and Veber's parameters (log P = 4.2; polar surface area = 167 Å). (b) Suggest five possible regions in saquinavir that might be susceptible to metabolism and identify the possible metabolite formed. N IZ || H ZI Ill Il Saquinavir I Z H H

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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