1. Which of the following is expected to be the most reactive towards electrophilic aromatic substitution? он NH, он NH2 CH, ČH, A B. 2. which of the following is expected to be the least reactive towards electrophilic aromatic substitution?
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![1. Which of the following is expe cted to be the most reactive towards electrophilic aromatic
substitution?
OH
NH2
он
NH2
ČH;
CH3
A
B.
2. Which of the following is expected to be the least reactive towards electrophilic aromatic
substitution?
OH
HO
CH,
CH,
OH
ÓCH,
NH,
ÓCH,
D
A
B
3. Arrange the compoundsin order of increasing reactivity towards bromination (least
reactive<mostreactive):
A. Nitrobenzene, Aniline, Anisole, Toluene
B. Aniline, Phenol, Acetophenone, Bromobenzene
C. lodobenzene, Toluene, Acetanilide, Benzalde hyde](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F8c42356b-1c70-48b0-b13e-575ef21a23cd%2Faad532b1-fec6-4321-b15e-595ab61a3f92%2F5g5nz2_processed.jpeg&w=3840&q=75)
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