1. Using the terms cis and trans (which are also known as coupled and repulsion, respectively) Describe the allelic configuration of the heterozygous F1 individual. 2. Determine the gene order and the map distances between the genes.

1. Using the terms cis and trans (which are also known as coupled and repulsion, respectively) Describe the allelic configuration of the heterozygous F1 individual. 2. Determine the gene order and the map distances between the genes.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter13: Genes, Chromosomes, And Human Genetics

Section: Chapter Questions

Problem 8TYK: Another gene in Drosophila determines wing length. The dominant wild-type allele of this gene...

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Question

**Genetic Linkage and Gene Mapping in Drosophila**

The recessive alleles k (kidney-shaped eyes), c (cardinal-colored eyes), and e (ebony body) identify three genes on chromosome 3 of Drosophila. Females with kidney-shaped eyes and ebony body color were mated with cardinal-colored eyed males. The resulting F1 progeny were completely wild type. When F1 females were testcrossed with the kk cc ee males, the following progeny phenotypes were obtained:

| Phenotype | Number |
|------------|--------|
| k + + | 53 |
| k + e | 876 |
| k c + | 48 |
| k c e | 8 |
| + + + | 6 |
| + + e | 63 |
| + c + | 899 |
| + c e | 49 |

**Total: 2000**

1. **Using the terms cis and trans (which are also known as coupled and repulsion, respectively) describe the allelic configuration of the heterozygous F1 individual.**

2. **Determine the gene order and the map distances between the genes.**

Please note the above table summarizes the observed phenotypes of the testcross progeny and their respective counts.

For gene mapping and determining distances:

- Identify the parental and recombinant phenotypes.
- Calculate recombinant frequencies to determine the distance between the genes.

**Example process for gene mapping:**
- Identify least frequent classes as double crossover events.
- Use these to determine gene order.
- Calculate the recombination frequencies for the regions between the genes using single crossover frequencies.

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