1. The structure for ibuprofen is shown below. A) Circle the most acidic proton on the molecule. B) What is the pKa of this proton? C) Draw the conjugate base of ibuprofen. ioson ibuprofen O-H

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1. The structure for ibuprofen is shown below. A) Circle the most acidic proton on the molecule. B) What is the
pKa of this proton? C) Draw the conjugate base of ibuprofen.
محمد
ibuprofen
LO-H
Transcribed Image Text:1. The structure for ibuprofen is shown below. A) Circle the most acidic proton on the molecule. B) What is the pKa of this proton? C) Draw the conjugate base of ibuprofen. محمد ibuprofen LO-H
Table 5.1
pka
-10
0
5
10
15
20
25
30
40
45
50
The pK values for types of compounds frequently encountered in
organic chemistry.
Compound types
Mineral acids (H₂SO4, HI, HBr, HCI); sulfonic acids (RSO3H)
H3O+, H3PO4
Carboxylic acids (RCOO H), HF, aromatic thiols (ArSH), HN3
Weak inorganic acids (H₂S, HCN, NH4+), amine salts (RNH³*), phenols (ArOH),
thiols (RSH), aromatic amides (ArNH-COR)
H₂O, alcohols (ROH), amides (RCONH₂)
Ketones (RCH₂COR')
Esters (RCH₂COOR), alkynes (RC=CH), nitriles (RCH₂CN)
Anilines (ArNH₂)
Ammonia (NH3), amines (RNH₂), benzylic C-H (ArCH₂X)
Arenes (ArH) and alkenes (RCH=CH₂)
Alkanes (RH)
Transcribed Image Text:Table 5.1 pka -10 0 5 10 15 20 25 30 40 45 50 The pK values for types of compounds frequently encountered in organic chemistry. Compound types Mineral acids (H₂SO4, HI, HBr, HCI); sulfonic acids (RSO3H) H3O+, H3PO4 Carboxylic acids (RCOO H), HF, aromatic thiols (ArSH), HN3 Weak inorganic acids (H₂S, HCN, NH4+), amine salts (RNH³*), phenols (ArOH), thiols (RSH), aromatic amides (ArNH-COR) H₂O, alcohols (ROH), amides (RCONH₂) Ketones (RCH₂COR') Esters (RCH₂COOR), alkynes (RC=CH), nitriles (RCH₂CN) Anilines (ArNH₂) Ammonia (NH3), amines (RNH₂), benzylic C-H (ArCH₂X) Arenes (ArH) and alkenes (RCH=CH₂) Alkanes (RH)
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